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Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

INTRODUCTION: AMP-activated protein kinase (AMPK) maintains cultured chondrocyte matrix homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes. Liver kinase B1 (LKB1) is one of the upstream activators of AMPK. Hence, we examined t...

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Detalles Bibliográficos
Autores principales:	Petursson, Freyr, Husa, Matt, June, Ron, Lotz, Martin, Terkeltaub, Robert, Liu-Bryan, Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979085/ https://www.ncbi.nlm.nih.gov/pubmed/23883619 http://dx.doi.org/10.1186/ar4254

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