High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

INTRODUCTION: Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes...

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Detalles Bibliográficos
Autores principales: Gawri, Rahul, Rosenzweig, Derek H, Krock, Emerson, Ouellet, Jean A, Stone, Laura S, Quinn, Thomas M, Haglund, Lisbet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979109/
https://www.ncbi.nlm.nih.gov/pubmed/24457003
http://dx.doi.org/10.1186/ar4449

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