Pregnancy offers new insights into mechanisms of breast cancer risk and resistance

Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets....

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Detalles Bibliográficos
Autores principales: Jerry, D Joseph, Makari-Judson, Grace, Crisi, Giovanna M, Dunphy, Karen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979118/
https://www.ncbi.nlm.nih.gov/pubmed/24060354
http://dx.doi.org/10.1186/bcr3482
Descripción
Sumario:Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies.

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