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Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment

INTRODUCTION: Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated protein kinase (MAPK) pathways results in anti-estrogen resistance in vitro, but a biomarker with clinical validity to predict intrinsic resistance has not been identified. In metastatic breast cancer patie...

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Detalles Bibliográficos
Autores principales:	Beelen, Karin, Opdam, Mark, Severson, Tesa M, Koornstra, Rutger HT, Vincent, Andrew D, Wesseling, Jelle, Muris, Jettie J, Berns, Els MJJ, Vermorken, Jan B, van Diest, Paul J, Linn, Sabine C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979131/ https://www.ncbi.nlm.nih.gov/pubmed/24447434 http://dx.doi.org/10.1186/bcr3598

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