Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury

Biomarkers of drug-induced liver injury (DILI) are essential for the diagnosis of severe cases of DILI in clinical trials and clinical practice, but the currently used biomarker paradigm detects damage after it has occurred and has limited prognostic value. The development of new biomarker strategie...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubrecht, Jiri, Schomaker, Shelli J, Amacher, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979132/
https://www.ncbi.nlm.nih.gov/pubmed/24073687
http://dx.doi.org/10.1186/gm489
_version_ 1782310693910872064
author Aubrecht, Jiri
Schomaker, Shelli J
Amacher, David E
author_facet Aubrecht, Jiri
Schomaker, Shelli J
Amacher, David E
author_sort Aubrecht, Jiri
collection PubMed
description Biomarkers of drug-induced liver injury (DILI) are essential for the diagnosis of severe cases of DILI in clinical trials and clinical practice, but the currently used biomarker paradigm detects damage after it has occurred and has limited prognostic value. The development of new biomarker strategies that improve the diagnosis of DILI by providing increased specificity and/or by identifying individual patients who are at risk for DILI is therefore crucial. See related Research, http://genomemedicine.com/content/5/9/86
format Online
Article
Text
id pubmed-3979132
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-39791322014-09-27 Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury Aubrecht, Jiri Schomaker, Shelli J Amacher, David E Genome Med Research Highlight Biomarkers of drug-induced liver injury (DILI) are essential for the diagnosis of severe cases of DILI in clinical trials and clinical practice, but the currently used biomarker paradigm detects damage after it has occurred and has limited prognostic value. The development of new biomarker strategies that improve the diagnosis of DILI by providing increased specificity and/or by identifying individual patients who are at risk for DILI is therefore crucial. See related Research, http://genomemedicine.com/content/5/9/86 BioMed Central 2013-09-27 /pmc/articles/PMC3979132/ /pubmed/24073687 http://dx.doi.org/10.1186/gm489 Text en Copyright © 2013 BioMed Central Ltd.
spellingShingle Research Highlight
Aubrecht, Jiri
Schomaker, Shelli J
Amacher, David E
Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title_full Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title_fullStr Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title_full_unstemmed Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title_short Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
title_sort emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979132/
https://www.ncbi.nlm.nih.gov/pubmed/24073687
http://dx.doi.org/10.1186/gm489
work_keys_str_mv AT aubrechtjiri emerginghepatotoxicitybiomarkersandtheirpotentialtoimproveunderstandingandmanagementofdruginducedliverinjury
AT schomakershellij emerginghepatotoxicitybiomarkersandtheirpotentialtoimproveunderstandingandmanagementofdruginducedliverinjury
AT amacherdavide emerginghepatotoxicitybiomarkersandtheirpotentialtoimproveunderstandingandmanagementofdruginducedliverinjury

Ejemplares similares