Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy

Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the diff...

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Detalles Bibliográficos
Autores principales: Zhu, Shouan, Liu, Huanhuan, Wu, Yan, Heng, Boon Chin, Chen, Pengfei, Liu, Hua, Ouyang, Hong Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979163/
https://www.ncbi.nlm.nih.gov/pubmed/23856044
http://dx.doi.org/10.1186/ar4240
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author Zhu, Shouan
Liu, Huanhuan
Wu, Yan
Heng, Boon Chin
Chen, Pengfei
Liu, Hua
Ouyang, Hong Wei
author_facet Zhu, Shouan
Liu, Huanhuan
Wu, Yan
Heng, Boon Chin
Chen, Pengfei
Liu, Hua
Ouyang, Hong Wei
author_sort Zhu, Shouan
collection PubMed
description Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of targeting Wnt and Rho GTPase for OA prognosis and therapy is suggested, which is instructive for clinical treatment of the disease.
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spelling pubmed-39791632014-04-09 Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy Zhu, Shouan Liu, Huanhuan Wu, Yan Heng, Boon Chin Chen, Pengfei Liu, Hua Ouyang, Hong Wei Arthritis Res Ther Review Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of targeting Wnt and Rho GTPase for OA prognosis and therapy is suggested, which is instructive for clinical treatment of the disease. BioMed Central 2013 2013-07-11 /pmc/articles/PMC3979163/ /pubmed/23856044 http://dx.doi.org/10.1186/ar4240 Text en Copyright © 2013 BioMed Central Ltd
spellingShingle Review
Zhu, Shouan
Liu, Huanhuan
Wu, Yan
Heng, Boon Chin
Chen, Pengfei
Liu, Hua
Ouyang, Hong Wei
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title_full Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title_fullStr Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title_full_unstemmed Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title_short Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
title_sort wnt and rho gtpase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979163/
https://www.ncbi.nlm.nih.gov/pubmed/23856044
http://dx.doi.org/10.1186/ar4240
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