RAPID RP HPLC METHOD FOR QUANTITATIVE DETERMINATION OF LORNOXICAM IN TABLETS

The objective of the study was to develop a simple, rapid, specific and precise reverse phase high performance liquid chromatographic method for the determination of lornoxicam in bulk and pharmaceutical preparations. Chromatographic separation of the drug was performed on a eclipse C18 column (150 mm × 4.6 mm, 5 μm) as stationary phase and mobile phase used is methanol: 0.1% formic acid in water (80:20 v/v), with a flow rate of 0.8 mL min(-1) and UV detection at 381 nm. The proposed method was validated for linearity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ). Linearity, accuracy and precision were found to be acceptable over the ranges of 0.5-20 μg/ml. It can be conveniently adopted for routine quality control analysis of lornoxicam.