Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles

PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared usi...

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Autores principales: Shabir, Anjumn, Alhusban, Farhan, Perrie, Yvonne, Mohammed, Afzal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979202/
https://www.ncbi.nlm.nih.gov/pubmed/24826005
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author Shabir, Anjumn
Alhusban, Farhan
Perrie, Yvonne
Mohammed, Afzal R.
author_facet Shabir, Anjumn
Alhusban, Farhan
Perrie, Yvonne
Mohammed, Afzal R.
author_sort Shabir, Anjumn
collection PubMed
description PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles
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spelling pubmed-39792022014-05-13 Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles Shabir, Anjumn Alhusban, Farhan Perrie, Yvonne Mohammed, Afzal R. J Basic Clin Pharm Original Article PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles Medknow Publications & Media Pvt Ltd 2011-03 2011-05-15 /pmc/articles/PMC3979202/ /pubmed/24826005 Text en Copyright: © Journal of Basic and Clinical Pharmacy http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shabir, Anjumn
Alhusban, Farhan
Perrie, Yvonne
Mohammed, Afzal R.
Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title_full Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title_fullStr Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title_full_unstemmed Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title_short Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles
title_sort effects of ball-milling on plga polymer and its implication on lansoprazole-loaded nanoparticles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979202/
https://www.ncbi.nlm.nih.gov/pubmed/24826005
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