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Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation

Ceftazidime is a broad spectrum third generation cephalosporin antibiotic which is effective mainly against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter and Enterobacteriaceae, the pathogens which most often cause ophthalmological infections. Unlike other commonly used beta l...

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Autores principales: Wijesooriya, Chamari, Budai, Marianna, Budai, Lívia, Szilasi, Magdolna E., Petrikovics, Ilona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979273/
https://www.ncbi.nlm.nih.gov/pubmed/24808675
http://dx.doi.org/10.4103/0976-0105.118810
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author Wijesooriya, Chamari
Budai, Marianna
Budai, Lívia
Szilasi, Magdolna E.
Petrikovics, Ilona
author_facet Wijesooriya, Chamari
Budai, Marianna
Budai, Lívia
Szilasi, Magdolna E.
Petrikovics, Ilona
author_sort Wijesooriya, Chamari
collection PubMed
description Ceftazidime is a broad spectrum third generation cephalosporin antibiotic which is effective mainly against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter and Enterobacteriaceae, the pathogens which most often cause ophthalmological infections. Unlike other commonly used beta lactam antibiotics, ceftazidime is resistant to several types of beta lactamases (e.g., TEM, SHV and PSE-1). Because of these advantages, ceftazidime is used in the treatment of eye infections. However, ceftazidime undergoes rapid degradation in aqueous solutions therefore eye drops containing ceftazidime in aqueous solutions are not commercially manufactured. In the present study, liposomal encapsulations of ceftazidime with various lipid compositions, hydrating solutions and pH-values have been studied in order to optimize liposomal composition for a potential eye drop formulation.
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spelling pubmed-39792732014-05-07 Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation Wijesooriya, Chamari Budai, Marianna Budai, Lívia Szilasi, Magdolna E. Petrikovics, Ilona J Basic Clin Pharm Original Article Ceftazidime is a broad spectrum third generation cephalosporin antibiotic which is effective mainly against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter and Enterobacteriaceae, the pathogens which most often cause ophthalmological infections. Unlike other commonly used beta lactam antibiotics, ceftazidime is resistant to several types of beta lactamases (e.g., TEM, SHV and PSE-1). Because of these advantages, ceftazidime is used in the treatment of eye infections. However, ceftazidime undergoes rapid degradation in aqueous solutions therefore eye drops containing ceftazidime in aqueous solutions are not commercially manufactured. In the present study, liposomal encapsulations of ceftazidime with various lipid compositions, hydrating solutions and pH-values have been studied in order to optimize liposomal composition for a potential eye drop formulation. Medknow Publications & Media Pvt Ltd 2013-06 /pmc/articles/PMC3979273/ /pubmed/24808675 http://dx.doi.org/10.4103/0976-0105.118810 Text en Copyright: © Journal of Basic and Clinical Pharmacy http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wijesooriya, Chamari
Budai, Marianna
Budai, Lívia
Szilasi, Magdolna E.
Petrikovics, Ilona
Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title_full Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title_fullStr Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title_full_unstemmed Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title_short Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
title_sort optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979273/
https://www.ncbi.nlm.nih.gov/pubmed/24808675
http://dx.doi.org/10.4103/0976-0105.118810
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