c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer

Metastasis suppressors comprise a growing class of genes whose downregulation triggers metastatic progression. In contrast to tumor suppressors, metastasis suppressors are rarely mutated or deleted, and little is known regarding the mechanisms by which their expression is downregulated. Here, we dem...

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Detalles Bibliográficos
Autores principales: Fiore, Leann S., Ganguly, Sourik S., Sledziona, James, Cibull, Michael L., Wang, Chi, Richards, Dana L., Neltner, Janna M., Beach, Carol, McCorkle, Joseph R., Kaetzel, David M., Plattner, Rina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979510/
https://www.ncbi.nlm.nih.gov/pubmed/24096484
http://dx.doi.org/10.1038/onc.2013.399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979510/
https://www.ncbi.nlm.nih.gov/pubmed/24096484
http://dx.doi.org/10.1038/onc.2013.399

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