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Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe

BACKGROUND: Whilst studies suggest that generalized anxiety disorder (GAD) represents a considerable health care burden in Europe, there is a paucity of published evidence. This study investigated the burden of illness associated with GAD across five European countries (France, Germany, Italy, Spain...

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Autores principales: Toghanian, Samira, DiBonaventura, Marco, Järbrink, Krister, Locklear, Julie C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979574/
https://www.ncbi.nlm.nih.gov/pubmed/24729720
http://dx.doi.org/10.2147/CEOR.S55429
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author Toghanian, Samira
DiBonaventura, Marco
Järbrink, Krister
Locklear, Julie C
author_facet Toghanian, Samira
DiBonaventura, Marco
Järbrink, Krister
Locklear, Julie C
author_sort Toghanian, Samira
collection PubMed
description BACKGROUND: Whilst studies suggest that generalized anxiety disorder (GAD) represents a considerable health care burden in Europe, there is a paucity of published evidence. This study investigated the burden of illness associated with GAD across five European countries (France, Germany, Italy, Spain, and the UK). METHODS: Information from the 2008 European National Health and Wellness Survey database was analyzed. Bivariate, multivariate, and cost analyses were used to compare patients with GAD and propensity-matched controls. RESULTS: Compared with non-GAD controls, patients with GAD had more comorbidities and were more likely to smoke but less likely to be employed, use alcohol, or take exercise. They also had significantly worse health-related quality of life, and significantly greater work impairment and resource use, which increased as GAD severity increased. Within-country analyses demonstrated results similar to those for the five European countries overall, with the largest differences in resource use between patients with GAD and non-GAD controls documented in France and Germany. The average mean differences in direct costs were relatively small between the GAD groups and controls; however, indirect costs differed substantially. Costs were particularly high in Germany, mainly due to higher salaries leading to higher costs associated with absence from work. The limitation of this study was that the data were from a self-reported Internet survey, making them subject to reporting bias and possibly sample bias. CONCLUSION: Across all five European countries, GAD had a significant impact on work impairment, resource use, and economic costs, representing a considerable individual and financial burden that increased with severity of disease. These data may help us to understand better the burden and costs associated with GAD.
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spelling pubmed-39795742014-04-11 Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe Toghanian, Samira DiBonaventura, Marco Järbrink, Krister Locklear, Julie C Clinicoecon Outcomes Res Original Research BACKGROUND: Whilst studies suggest that generalized anxiety disorder (GAD) represents a considerable health care burden in Europe, there is a paucity of published evidence. This study investigated the burden of illness associated with GAD across five European countries (France, Germany, Italy, Spain, and the UK). METHODS: Information from the 2008 European National Health and Wellness Survey database was analyzed. Bivariate, multivariate, and cost analyses were used to compare patients with GAD and propensity-matched controls. RESULTS: Compared with non-GAD controls, patients with GAD had more comorbidities and were more likely to smoke but less likely to be employed, use alcohol, or take exercise. They also had significantly worse health-related quality of life, and significantly greater work impairment and resource use, which increased as GAD severity increased. Within-country analyses demonstrated results similar to those for the five European countries overall, with the largest differences in resource use between patients with GAD and non-GAD controls documented in France and Germany. The average mean differences in direct costs were relatively small between the GAD groups and controls; however, indirect costs differed substantially. Costs were particularly high in Germany, mainly due to higher salaries leading to higher costs associated with absence from work. The limitation of this study was that the data were from a self-reported Internet survey, making them subject to reporting bias and possibly sample bias. CONCLUSION: Across all five European countries, GAD had a significant impact on work impairment, resource use, and economic costs, representing a considerable individual and financial burden that increased with severity of disease. These data may help us to understand better the burden and costs associated with GAD. Dove Medical Press 2014-04-02 /pmc/articles/PMC3979574/ /pubmed/24729720 http://dx.doi.org/10.2147/CEOR.S55429 Text en © 2014 Toghanian et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Toghanian, Samira
DiBonaventura, Marco
Järbrink, Krister
Locklear, Julie C
Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title_full Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title_fullStr Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title_full_unstemmed Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title_short Economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in Europe
title_sort economic and humanistic burden of illness in generalized anxiety disorder: an analysis of patient survey data in europe
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979574/
https://www.ncbi.nlm.nih.gov/pubmed/24729720
http://dx.doi.org/10.2147/CEOR.S55429
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