Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles

We have examined cell-cycle dependence of chromosomal aberration induction and cell killing after high or low dose-rate γ irradiation in cells bearing DNA-PKcs mutations in the S2056 cluster, the T2609 cluster, or the kinase domain. We also compared sister chromatid exchanges (SCE) production by ver...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Fen, Nagasawa, Hatsumi, Little, John B., Kato, Takamitsu A., Shih, Hung-Ying, Xie, Xian-Jin, Wilson Jr., Paul F., Brogan, John R., Kurimasa, Akihiro, Chen, David J., Bedford, Joel S., Chen, Benjamin P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979685/
https://www.ncbi.nlm.nih.gov/pubmed/24714417
http://dx.doi.org/10.1371/journal.pone.0093579

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