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Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study
Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functiona...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979738/ https://www.ncbi.nlm.nih.gov/pubmed/24714805 http://dx.doi.org/10.1371/journal.pone.0094115 |
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author | Itahashi, Takashi Yamada, Takashi Watanabe, Hiromi Nakamura, Motoaki Jimbo, Daiki Shioda, Seiji Toriizuka, Kazuo Kato, Nobumasa Hashimoto, Ryuichiro |
author_facet | Itahashi, Takashi Yamada, Takashi Watanabe, Hiromi Nakamura, Motoaki Jimbo, Daiki Shioda, Seiji Toriizuka, Kazuo Kato, Nobumasa Hashimoto, Ryuichiro |
author_sort | Itahashi, Takashi |
collection | PubMed |
description | Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functional connectivity in the adult ASC brain, such functional alterations at the network level have not yet been fully characterized within the recently developed graph-theoretical framework. Here, we applied a graph-theoretical analysis to resting-state fMRI data acquired from 46 adults with ASC and 46 age- and gender-matched controls, to investigate the topological properties and organization of autistic brain network. Analyses of global metrics revealed that, relative to the controls, participants with ASC exhibited significant decreases in clustering coefficient and characteristic path length, indicating a shift towards randomized organization. Furthermore, analyses of local metrics revealed a significantly altered organization of the hub nodes in ASC, as shown by analyses of hub disruption indices using multiple local metrics and by a loss of “hubness” in several nodes (e.g., the bilateral superior temporal sulcus, right dorsolateral prefrontal cortex, and precuneus) that are critical for social and non-social cognitive functions. In particular, local metrics of the anterior cingulate cortex consistently showed significant negative correlations with the Autism-Spectrum Quotient score. Our results demonstrate altered patterns of global and local topological properties that may underlie impaired social and non-social cognition in ASC. |
format | Online Article Text |
id | pubmed-3979738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39797382014-04-11 Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study Itahashi, Takashi Yamada, Takashi Watanabe, Hiromi Nakamura, Motoaki Jimbo, Daiki Shioda, Seiji Toriizuka, Kazuo Kato, Nobumasa Hashimoto, Ryuichiro PLoS One Research Article Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functional connectivity in the adult ASC brain, such functional alterations at the network level have not yet been fully characterized within the recently developed graph-theoretical framework. Here, we applied a graph-theoretical analysis to resting-state fMRI data acquired from 46 adults with ASC and 46 age- and gender-matched controls, to investigate the topological properties and organization of autistic brain network. Analyses of global metrics revealed that, relative to the controls, participants with ASC exhibited significant decreases in clustering coefficient and characteristic path length, indicating a shift towards randomized organization. Furthermore, analyses of local metrics revealed a significantly altered organization of the hub nodes in ASC, as shown by analyses of hub disruption indices using multiple local metrics and by a loss of “hubness” in several nodes (e.g., the bilateral superior temporal sulcus, right dorsolateral prefrontal cortex, and precuneus) that are critical for social and non-social cognitive functions. In particular, local metrics of the anterior cingulate cortex consistently showed significant negative correlations with the Autism-Spectrum Quotient score. Our results demonstrate altered patterns of global and local topological properties that may underlie impaired social and non-social cognition in ASC. Public Library of Science 2014-04-08 /pmc/articles/PMC3979738/ /pubmed/24714805 http://dx.doi.org/10.1371/journal.pone.0094115 Text en © 2014 Itahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Itahashi, Takashi Yamada, Takashi Watanabe, Hiromi Nakamura, Motoaki Jimbo, Daiki Shioda, Seiji Toriizuka, Kazuo Kato, Nobumasa Hashimoto, Ryuichiro Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title | Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title_full | Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title_fullStr | Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title_full_unstemmed | Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title_short | Altered Network Topologies and Hub Organization in Adults with Autism: A Resting-State fMRI Study |
title_sort | altered network topologies and hub organization in adults with autism: a resting-state fmri study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979738/ https://www.ncbi.nlm.nih.gov/pubmed/24714805 http://dx.doi.org/10.1371/journal.pone.0094115 |
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