Impact of Mutations in Highly Conserved Amino Acids of the HIV-1 Gag-p24 and Env-gp120 Proteins on Viral Replication in Different Genetic Backgrounds

It has been hypothesized that a single mutation at a highly conserved amino acid site (HCS) can be severely deleterious to HIV in most if not all isolate-specific genetic backgrounds. Consequently, potentially universal HIV-1 vaccines exclusively targeting highly conserved regions of the viral prote...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Rao, Ushnal, McClure, Jan, Konopa, Philip, Manocheewa, Siriphan, Kim, Moon, Chen, Lennie, Troyer, Ryan M., Tebit, Denis M., Holte, Sarah, Arts, Eric J., Mullins, James I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979772/
https://www.ncbi.nlm.nih.gov/pubmed/24713822
http://dx.doi.org/10.1371/journal.pone.0094240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979772/
https://www.ncbi.nlm.nih.gov/pubmed/24713822
http://dx.doi.org/10.1371/journal.pone.0094240

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