Cargando…

The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle

Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Wootae, Choi, Minji, Kim, Ja-Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979909/ https://www.ncbi.nlm.nih.gov/pubmed/24526115 http://dx.doi.org/10.4161/cc.28104

Ejemplares similares

The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis
por: Yang, Di, et al.
Publicado: (2022)

The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis
por: Gao, Yanpan, et al.
Publicado: (2018)

TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L
por: An, Cheng, et al.
Publicado: (2017)

Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells
por: Lin, Huijuan, et al.
Publicado: (2022)

Correction: The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis
por: Yang, Di, et al.
Publicado: (2022)

TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast
por: Wanat, Jennifer J., et al.
Publicado: (2018)

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
por: Vatapalli, R., et al.
Publicado: (2020)

The Putative Histone Methyltransferase DOT1 Regulates Aflatoxin and Pathogenicity Attributes in Aspergillus flavus
por: Liang, Linlin, et al.
Publicado: (2017)

Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation
por: Aslam, Muhammad Assad, et al.
Publicado: (2021)

Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression
por: Shan, Lin, et al.
Publicado: (2022)

Histone Methyltransferase DOT1L as a Promising Epigenetic Target for Treatment of Solid Tumors
por: Alexandrova, Elena, et al.
Publicado: (2022)

Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
por: FitzGerald, Jennifer, et al.
Publicado: (2011)

Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase‐Dependent Apoptosis in Cerebral Ischemia/Reperfusion
por: Wang, Jinghuan, et al.
Publicado: (2021)

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack
por: Oksenych, Valentyn, et al.
Publicado: (2013)

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias
por: Yi, Yan, et al.
Publicado: (2022)

DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin
por: Feng, Yi, et al.
Publicado: (2022)

Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy
por: Mao, Yu, et al.
Publicado: (2021)

Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation
por: Xu, Bo, et al.
Publicado: (2022)

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8(+) T cells
por: Kwesi-Maliepaard, Eliza Mari, et al.
Publicado: (2020)

The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells
por: Salvati, Annamaria, et al.
Publicado: (2019)

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
por: Jones, Brendan, et al.
Publicado: (2008)

Histone Methyltransferase DOT1L Is Involved in Larval Molting and Second Stage Nymphal Feeding in Ornithodoros moubata
por: Gobl, Julia, et al.
Publicado: (2020)

Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction
por: Xu, Jie, et al.
Publicado: (2022)

Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer
por: Byun, Woong Sub, et al.
Publicado: (2019)

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
por: Jang, Seongmin, et al.
Publicado: (2019)

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase
por: Anderson, Cathy J., et al.
Publicado: (2019)

Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity
por: Malcom, Carrie A., et al.
Publicado: (2022)

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
por: Kari, Vijayalakshmi, et al.
Publicado: (2019)

A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1
por: Si, Yang, et al.
Publicado: (2022)

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
por: Nassa, Giovanni, et al.
Publicado: (2019)

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties
por: Stulemeijer, Iris J. E., et al.
Publicado: (2015)

The Indispensable Role of Histone Methyltransferase PoDot1 in Extracellular Glycoside Hydrolase Biosynthesis of Penicillium oxalicum
por: Li, Yanan, et al.
Publicado: (2019)

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast
por: Lee, Soyun, et al.
Publicado: (2018)

Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis
por: Matsuura, Kazuo, et al.
Publicado: (2012)

Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer
por: Alexandrova, Elena, et al.
Publicado: (2022)

Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres
por: Lazzaro, Federico, et al.
Publicado: (2008)

DOT1L is a barrier to histone acetylation during reprogramming to pluripotency
por: Wille, Coral K., et al.
Publicado: (2023)

CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells
por: Kim, Wootae, et al.
Publicado: (2019)

CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis
por: Liu, Chaohua, et al.
Publicado: (2020)

Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
por: Yang, Liqun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m1sservqr4353u4k52dq96f27i