Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway

KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on a...

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Detalles Bibliográficos
Autores principales: Marzo, S., Galimberti, V., Biggiogera, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980215/
https://www.ncbi.nlm.nih.gov/pubmed/24705002
http://dx.doi.org/10.4081/ejh.2014.2358
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author Marzo, S.
Galimberti, V.
Biggiogera, M.
author_facet Marzo, S.
Galimberti, V.
Biggiogera, M.
author_sort Marzo, S.
collection PubMed
description KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.
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spelling pubmed-39802152014-04-17 Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway Marzo, S. Galimberti, V. Biggiogera, M. Eur J Histochem Brief Report KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus. PAGEPress Publications, Pavia, Italy 2014-03-11 /pmc/articles/PMC3980215/ /pubmed/24705002 http://dx.doi.org/10.4081/ejh.2014.2358 Text en ©Copyright S. Marzo et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Marzo, S.
Galimberti, V.
Biggiogera, M.
Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title_full Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title_fullStr Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title_full_unstemmed Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title_short Unexpected Distribution of KRIT1 Inside the Nucleus: New Insight in a Complex Molecular Pathway
title_sort unexpected distribution of krit1 inside the nucleus: new insight in a complex molecular pathway
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980215/
https://www.ncbi.nlm.nih.gov/pubmed/24705002
http://dx.doi.org/10.4081/ejh.2014.2358
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