The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clin...

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Detalles Bibliográficos
Autores principales: Banys, Malgorzata, Krawczyk, Natalia, Fehm, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980614/
https://www.ncbi.nlm.nih.gov/pubmed/24434543
http://dx.doi.org/10.3390/cancers6010143
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author Banys, Malgorzata
Krawczyk, Natalia
Fehm, Tanja
author_facet Banys, Malgorzata
Krawczyk, Natalia
Fehm, Tanja
author_sort Banys, Malgorzata
collection PubMed
description Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.
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spelling pubmed-39806142014-04-09 The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer Banys, Malgorzata Krawczyk, Natalia Fehm, Tanja Cancers (Basel) Review Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer. MDPI 2014-01-15 /pmc/articles/PMC3980614/ /pubmed/24434543 http://dx.doi.org/10.3390/cancers6010143 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Banys, Malgorzata
Krawczyk, Natalia
Fehm, Tanja
The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_full The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_fullStr The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_full_unstemmed The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_short The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_sort role and clinical relevance of disseminated tumor cells in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980614/
https://www.ncbi.nlm.nih.gov/pubmed/24434543
http://dx.doi.org/10.3390/cancers6010143
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