Cargando…

Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression

Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs), in development and progression of different tumor types. In normal cells, the activation of TRPV2 channels by growth factors, hormones, and endocannabinoids induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liberati, Sonia, Morelli, Maria Beatrice, Amantini, Consuelo, Farfariello, Valerio, Santoni, Matteo, Conti, Alessandro, Nabissi, Massimo, Cascinu, Stefano, Santoni, Giorgio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980744/ https://www.ncbi.nlm.nih.gov/pubmed/24709905 http://dx.doi.org/10.3390/cells3010112

Ejemplares similares

Correction: Liberati, S., et al. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells 2014, 3, 112–128
por: Liberati, Sonia, et al.
Publicado: (2014)

The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses
por: Santoni, Giorgio, et al.
Publicado: (2013)

The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity
por: Amantini, Consuelo, et al.
Publicado: (2017)

Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells
por: Amantini, Consuelo, et al.
Publicado: (2015)

Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients
por: Nabissi, Massimo, et al.
Publicado: (2016)

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner
por: Amantini, Consuelo, et al.
Publicado: (2016)

Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses
por: Santoni, Giorgio, et al.
Publicado: (2020)

Cross-talk between alpha(1D)-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation
por: Morelli, Maria Beatrice, et al.
Publicado: (2014)

Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder
por: Santoni, Giorgio, et al.
Publicado: (2012)

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons
por: Santoni, Giorgio, et al.
Publicado: (2015)

Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib
por: Maggi, Federica, et al.
Publicado: (2023)

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses
por: Santoni, Giorgio, et al.
Publicado: (2018)

The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
por: Maggi, Federica, et al.
Publicado: (2022)

Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients
por: Santoni, Giorgio, et al.
Publicado: (2022)

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells
por: Morelli, Maria Beatrice, et al.
Publicado: (2015)

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner
por: Morelli, Maria Beatrice, et al.
Publicado: (2016)

Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
por: Morelli, Maria Beatrice, et al.
Publicado: (2022)

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients
por: Morelli, Maria Beatrice, et al.
Publicado: (2022)

Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells
por: Santoni, M, et al.
Publicado: (2013)

Coexpression of TRPML1 and TRPML2 Mucolipin Channels Affects the Survival of Glioblastoma Patients
por: Santoni, Giorgio, et al.
Publicado: (2022)

The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer
por: Marinelli, Oliviero, et al.
Publicado: (2020)

Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient’s Survival
por: Morelli, Maria Beatrice, et al.
Publicado: (2019)

Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
por: Santoni, Giorgio, et al.
Publicado: (2020)

ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines
por: Santoni, Giorgio, et al.
Publicado: (2021)

Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER(+)HER2(−)Rb wild-type and knock-down in breast cancer cell lines
por: Marinelli, Oliviero, et al.
Publicado: (2020)

Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines
por: Santoni, Giorgio, et al.
Publicado: (2021)

The Transient Receptor Potential Vanilloid Type-2 (TRPV2) Ion Channels in Neurogenesis and Gliomagenesis: Cross-Talk between Transcription Factors and Signaling Molecules
por: Santoni, Giorgio, et al.
Publicado: (2019)

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update
por: Maggi, Federica, et al.
Publicado: (2021)

Mechanosensation and Mechanotransduction in Natural Killer Cells
por: Santoni, Giorgio, et al.
Publicado: (2021)

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration
por: Nabissi, Massimo, et al.
Publicado: (2016)

Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma
por: Conti, Alessandro, et al.
Publicado: (2013)

The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment
por: Santoni, Giorgio, et al.
Publicado: (2022)

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression
por: Morelli, Maria Beatrice, et al.
Publicado: (2016)

The Controversial Role of PD-1 and Its Ligands in Gynecological Malignancies
por: Marinelli, Oliviero, et al.
Publicado: (2019)

Evening Primrose Oil Improves Chemotherapeutic Effects in Human Pancreatic Ductal Adenocarcinoma Cell Lines—A Preclinical Study
por: Zeppa, Laura, et al.
Publicado: (2022)

High CTLA-4 expression correlates with poor prognosis in thymoma patients
por: Santoni, Giorgio, et al.
Publicado: (2018)

CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
por: Santoni, Matteo, et al.
Publicado: (2014)

Correlation between High PD-L1 and EMT/Invasive Genes Expression and Reduced Recurrence-Free Survival in Blood-Circulating Tumor Cells from Patients with Non-Muscle-Invasive Bladder Cancer
por: Morelli, Maria Beatrice, et al.
Publicado: (2021)

Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival
por: Amantini, Consuelo, et al.
Publicado: (2019)

Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines
por: Luongo, Margherita, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fss53t4hscvii18nf3hbk204cc