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When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase

Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell...

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Detalles Bibliográficos
Autores principales: Brix, Ditte Marie, Bundgaard Clemmensen, Knut Kristoffer, Kallunki, Tuula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980748/
https://www.ncbi.nlm.nih.gov/pubmed/24709902
http://dx.doi.org/10.3390/cells3010053
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author Brix, Ditte Marie
Bundgaard Clemmensen, Knut Kristoffer
Kallunki, Tuula
author_facet Brix, Ditte Marie
Bundgaard Clemmensen, Knut Kristoffer
Kallunki, Tuula
author_sort Brix, Ditte Marie
collection PubMed
description Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell proliferation and survival and is needed for normal physiological activities, such as heart function and development of the nervous system. How does ErbB2 activation make cancer cells invasive and when? Comprehensive understanding of the cellular mechanisms leading to ErbB2-induced malignant processes is necessary for answering these questions. Here we present current knowledge about the invasion-promoting function of ErbB2 and the mechanisms involved in it. Obtaining detailed information about the “bad” behavior of ErbB2 can facilitate development of novel treatments against ErbB2-positive cancers.
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spelling pubmed-39807482014-04-11 When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase Brix, Ditte Marie Bundgaard Clemmensen, Knut Kristoffer Kallunki, Tuula Cells Review Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell proliferation and survival and is needed for normal physiological activities, such as heart function and development of the nervous system. How does ErbB2 activation make cancer cells invasive and when? Comprehensive understanding of the cellular mechanisms leading to ErbB2-induced malignant processes is necessary for answering these questions. Here we present current knowledge about the invasion-promoting function of ErbB2 and the mechanisms involved in it. Obtaining detailed information about the “bad” behavior of ErbB2 can facilitate development of novel treatments against ErbB2-positive cancers. MDPI 2014-01-27 /pmc/articles/PMC3980748/ /pubmed/24709902 http://dx.doi.org/10.3390/cells3010053 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Brix, Ditte Marie
Bundgaard Clemmensen, Knut Kristoffer
Kallunki, Tuula
When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title_full When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title_fullStr When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title_full_unstemmed When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title_short When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
title_sort when good turns bad: regulation of invasion and metastasis by erbb2 receptor tyrosine kinase
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980748/
https://www.ncbi.nlm.nih.gov/pubmed/24709902
http://dx.doi.org/10.3390/cells3010053
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