Cargando…
When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980748/ https://www.ncbi.nlm.nih.gov/pubmed/24709902 http://dx.doi.org/10.3390/cells3010053 |
_version_ | 1782479574925312000 |
---|---|
author | Brix, Ditte Marie Bundgaard Clemmensen, Knut Kristoffer Kallunki, Tuula |
author_facet | Brix, Ditte Marie Bundgaard Clemmensen, Knut Kristoffer Kallunki, Tuula |
author_sort | Brix, Ditte Marie |
collection | PubMed |
description | Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell proliferation and survival and is needed for normal physiological activities, such as heart function and development of the nervous system. How does ErbB2 activation make cancer cells invasive and when? Comprehensive understanding of the cellular mechanisms leading to ErbB2-induced malignant processes is necessary for answering these questions. Here we present current knowledge about the invasion-promoting function of ErbB2 and the mechanisms involved in it. Obtaining detailed information about the “bad” behavior of ErbB2 can facilitate development of novel treatments against ErbB2-positive cancers. |
format | Online Article Text |
id | pubmed-3980748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-39807482014-04-11 When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase Brix, Ditte Marie Bundgaard Clemmensen, Knut Kristoffer Kallunki, Tuula Cells Review Overexpression and activation of ErbB2 receptor tyrosine kinase in breast cancer is strongly linked to an aggressive disease with high potential for invasion and metastasis. In addition to inducing very aggressive, metastatic cancer, ErbB2 activation mediates processes such as increased cancer cell proliferation and survival and is needed for normal physiological activities, such as heart function and development of the nervous system. How does ErbB2 activation make cancer cells invasive and when? Comprehensive understanding of the cellular mechanisms leading to ErbB2-induced malignant processes is necessary for answering these questions. Here we present current knowledge about the invasion-promoting function of ErbB2 and the mechanisms involved in it. Obtaining detailed information about the “bad” behavior of ErbB2 can facilitate development of novel treatments against ErbB2-positive cancers. MDPI 2014-01-27 /pmc/articles/PMC3980748/ /pubmed/24709902 http://dx.doi.org/10.3390/cells3010053 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Brix, Ditte Marie Bundgaard Clemmensen, Knut Kristoffer Kallunki, Tuula When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title | When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title_full | When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title_fullStr | When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title_full_unstemmed | When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title_short | When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase |
title_sort | when good turns bad: regulation of invasion and metastasis by erbb2 receptor tyrosine kinase |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980748/ https://www.ncbi.nlm.nih.gov/pubmed/24709902 http://dx.doi.org/10.3390/cells3010053 |
work_keys_str_mv | AT brixdittemarie whengoodturnsbadregulationofinvasionandmetastasisbyerbb2receptortyrosinekinase AT bundgaardclemmensenknutkristoffer whengoodturnsbadregulationofinvasionandmetastasisbyerbb2receptortyrosinekinase AT kallunkituula whengoodturnsbadregulationofinvasionandmetastasisbyerbb2receptortyrosinekinase |