Cargando…

High performance CHO cell line development platform for enhanced production of recombinant proteins including difficult-to-express proteins

Detalles Bibliográficos
Autores principales:	Girod, Pierre-Alain, Le Fourn, Valérie, Calabrese, David, Regamey, Alexandre, Ley, Deborah, Mermod, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980810/ http://dx.doi.org/10.1186/1753-6561-7-S6-P75

Ejemplares similares

Influence of cytoskeleton organization on recombinant protein expression by CHO cells
por: Pourcel, Lucille, et al.
Publicado: (2020)

Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells
por: Berger, Audrey, et al.
Publicado: (2020)

MAR Elements and Transposons for Improved Transgene Integration and Expression
por: Ley, Déborah, et al.
Publicado: (2013)

MAR‐Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering
por: Kostyrko, Kaja, et al.
Publicado: (2016)

Use of MAR Elements to Increase the Production of Recombinant Proteins
por: Gorman, Cori, et al.
Publicado: (2009)

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies
por: Bale, Shridhar, et al.
Publicado: (2018)

Generation of genetically engineered CHO cell lines to support the production of a difficult to express therapeutic protein
por: Laux, Holger, et al.
Publicado: (2013)

Genome‐wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics
por: Kuhn, Alexandre, et al.
Publicado: (2020)

Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells
por: Pilbrough, Warren, et al.
Publicado: (2009)

miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line development
por: Fischer, Simon, et al.
Publicado: (2017)

Systems biology of unfolded protein response in recombinant CHO cells
por: Segar, Kamal Prashad, et al.
Publicado: (2013)

Progress in fed-batch culture for recombinant protein production in CHO cells
por: Xu, Wen-Jing, et al.
Publicado: (2023)

Rich production media as a platform for CHO cell line development
por: Kim, Yong Jae, et al.
Publicado: (2020)

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins
por: Malm, Magdalena, et al.
Publicado: (2022)

Metabolic engineering of CHO cells for the development of a robust protein production platform
por: Gupta, Sanjeev Kumar, et al.
Publicado: (2017)

Rapid recombinant protein production from pools of transposon-generated CHO cells
por: Matasci, Mattia, et al.
Publicado: (2011)

Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
por: Chevallier, Valentine, et al.
Publicado: (2019)

The Effect of microRNA on the Production of Recombinant Protein in CHO Cells and its Mechanism
por: Liu, Hui-Ning, et al.
Publicado: (2022)

High-level transgene expression by homologous recombination-mediated gene transfer
por: Grandjean, Mélanie, et al.
Publicado: (2011)

CHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles
por: Winkler, Karsten, et al.
Publicado: (2013)

Characterization of recombinant IgA producing CHO cell lines by qPCR
por: Reinhart, David, et al.
Publicado: (2013)

SYNCHRONIZATION OF MITOCHONDRIAL DNA SYNTHESIS IN CHINESE HAMSTER CELLS (LINE CHO) DEPRIVED OF ISOLEUCINE
por: Ley, Kenneth D., et al.
Publicado: (1973)

Influence of glutamine on transient and stable recombinant protein production in CHO and HEK-293 cells
por: Rajendra, Yashas, et al.
Publicado: (2011)

Stable overexpression of miR-17 enhances recombinant protein production of CHO cells()
por: Jadhav, Vaibhav, et al.
Publicado: (2014)

Impact of iron raw materials and their impurities on CHO metabolism and recombinant protein product quality
por: Weiss, Christine H., et al.
Publicado: (2021)

Cell-Free Systems Based on CHO Cell Lysates: Optimization Strategies, Synthesis of “Difficult-to-Express” Proteins and Future Perspectives
por: Thoring, Lena, et al.
Publicado: (2016)

MALDI-TOF mass spectrometry biotyping: At line monitoring of recombinant CHO cell cultures
por: Schwamb, Sebastian, et al.
Publicado: (2015)

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
por: Mahé, Amélie, et al.
Publicado: (2021)

High-yield production of “difficult-to-express” proteins in a continuous exchange cell-free system based on CHO cell lysates
por: Thoring, Lena, et al.
Publicado: (2017)

The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines
por: Edros, Raihana, et al.
Publicado: (2014)

Evaluation of effectiveness of protein expression of DNA vaccine in CHO Cells
por: Brum, Alexandre, et al.
Publicado: (2014)

Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones
por: Jamnikar, Uros, et al.
Publicado: (2015)

Retraction Note: Impact of different promoters, promoter mutation, and an enhancer on recombinant protein expression in CHO cells
por: Wang, Wen, et al.
Publicado: (2018)

RETRACTED ARTICLE: Impact of different promoters, promoter mutation, and an enhancer on recombinant protein expression in CHO cells
por: Wang, Wen, et al.
Publicado: (2017)

Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production
por: Budge, James D., et al.
Publicado: (2020)

Engineering of CHO cells for the production of vertebrate recombinant sialyltransferases
por: Houeix, Benoit, et al.
Publicado: (2019)

Controllability Analysis of Protein Glycosylation in Cho Cells
por: St. Amand, Melissa M., et al.
Publicado: (2014)

Knockout of caspase-7 gene improves the expression of recombinant protein in CHO cell line through the cell cycle arrest in G2/M phase
por: Safari, Fatemeh, et al.
Publicado: (2022)

Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform
por: Ghorbaniaghdam, Atefeh, et al.
Publicado: (2014)

Optimized platform medium and feed for rCHO cell lines using the CHEF1(® )expression system
por: Paul, William, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sa4sv5nr093s7ljist36pg6j46