Cargando…

Process development and optimization of fed-batch production processes for therapeutic proteins by CHO cells

Detalles Bibliográficos
Autores principales:	Clincke, Marie-Françoise, Harmsen, Mareike, Malphettes, Laetitia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980979/ http://dx.doi.org/10.1186/1753-6561-7-S6-P79

Ejemplares similares

Feeding strategy optimization in interaction with target seeding density of a fed-batch process for monoclonal antibody production
por: Clincke, Marie-Françoise, et al.
Publicado: (2013)

Chemically modified cysteine in CHO fed-batch processes and impact on the specific productivity
por: Hecklau, Caroline, et al.
Publicado: (2015)

Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells
por: Kochanowski, Nadine, et al.
Publicado: (2011)

The successful transfer of a modern CHO fed-batch process to different single-use bioreactors
por: Ruhl, Sebastian, et al.
Publicado: (2013)

Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
por: Ben Yahia, Bassem, et al.
Publicado: (2016)

From Clone Selection to 80L Bioreactor Production: Better, Faster, Leaner
por: Clincke, Marie-Françoise, et al.
Publicado: (2015)

Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development
por: Delouvroy, Frédéric, et al.
Publicado: (2013)

Media optimization for CHO fed-batch processes using a DoE approach in automated high-throughput single use ambr15 bioreactors
por: Grimm, Christophe, et al.
Publicado: (2015)

Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process
por: Harmsen, Mareike, et al.
Publicado: (2011)

Effect of iron sources on the glycosylation macroheterogeneity of human recombinant IFN-γ produced by CHO cells during batch processes
por: Clincke, Marie-Françoise, et al.
Publicado: (2011)

Rapid intensification of an established CHO cell fed‐batch process
por: Schulze, Markus, et al.
Publicado: (2021)

Profiling of glycosylation gene expression in CHO fed-batch cultures in response to glycosylation-enhancing medium components
por: Boniface, Ryan, et al.
Publicado: (2013)

Scale-up considerations for monoclonal antibody production process: an oxygen transfer flux approach
por: Gimenez, Laura, et al.
Publicado: (2013)

Selection of chemically defined media for CHO cell fed-batch culture processes
por: Pan, Xiao, et al.
Publicado: (2016)

ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
por: Delouvroy, Frédéric, et al.
Publicado: (2015)

Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch
por: Ferreira Vaz, Michelle Rossana, et al.
Publicado: (2014)

Progress in fed-batch culture for recombinant protein production in CHO cells
por: Xu, Wen-Jing, et al.
Publicado: (2023)

Protein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
por: Vergara, Mauricio, et al.
Publicado: (2013)

Model-based DoE for feed batch cultivation of a CHO cell line
por: Möllerl, Johannes, et al.
Publicado: (2015)

Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate
por: Clincke, Marie-Françoise, et al.
Publicado: (2011)

Technology transfer and scale down model development strategy for biotherapeutics produced in mammalian cells
por: Kochanowski, Nadine, et al.
Publicado: (2013)

Transcriptomic analysis reveals mode of action of butyric acid supplementation in an intensified CHO cell fed‐batch process
por: Schulze, Markus, et al.
Publicado: (2022)

Very High Density of CHO Cells in Perfusion by ATF or TFF in WAVE Bioreactor™. Part I. Effect of the Cell Density on the Process
por: Clincke, Marie-Françoise, et al.
Publicado: (2013)

Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
por: Chevallier, Valentine, et al.
Publicado: (2019)

Identification of process relevant miRNA in CHO cell lines - Process profiling reveals interesting targets for cell line engineering
por: Stiefel, Fabian, et al.
Publicado: (2013)

Hybrid deep modeling of a CHO-K1 fed-batch process: combining first-principles with deep neural networks
por: Pinto, José, et al.
Publicado: (2023)

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
por: Mahé, Amélie, et al.
Publicado: (2021)

Improved fed-batch bioprocesses using chemically modified amino acids in concentrated feeds
por: Mueller, Ronja, et al.
Publicado: (2013)

Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris
por: Maurer, Michael, et al.
Publicado: (2006)

Generation of genetically engineered CHO cell lines to support the production of a difficult to express therapeutic protein
por: Laux, Holger, et al.
Publicado: (2013)

Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
por: Chevallier, Valentine, et al.
Publicado: (2020)

Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
por: Pan, Xiao, et al.
Publicado: (2017)

Host cell protein platform assay development for therapeutic mAb bioprocessing using mammalian cells
por: Kochanowski, Nadine, et al.
Publicado: (2015)

Influence of cell culture media and feed supplements on cell metabolism and quality of IgG produced in CHO-K1, CHO-S, and CHO-DG44
por: Reinhart, David, et al.
Publicado: (2015)

Improvement of production rate on recombinant CHO cells in two-stage culture
por: Matsuoka, Hiroshi, et al.
Publicado: (2013)

Differences in the production of hyperglycosylated IFN alpha in CHO and HEK 293 cells
por: Gugliotta, Agustina, et al.
Publicado: (2013)

Benchmarking of commercially available CHO cell culture media for antibody production
por: Reinhart, David, et al.
Publicado: (2013)

Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations
por: Schwab, Karen, et al.
Publicado: (2017)

Development and evaluation of a new, specially tailored CHO media platform
por: Beckmann, Tim F, et al.
Publicado: (2013)

Overcoming the clarification challenges of high cell density culture
por: Gimenez, Laura, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_m8q7nhiu53peequgtguidbrq9q