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Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis

Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subj...

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Autores principales: Al Harthi, Fahad, Huraib, Ghaleb Bin, Zouman, Abdulrahman, Arfin, Misbahul, Tariq, Mohammad, Al-Asmari, Abdulrahaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981009/
https://www.ncbi.nlm.nih.gov/pubmed/24782577
http://dx.doi.org/10.1155/2014/239645
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author Al Harthi, Fahad
Huraib, Ghaleb Bin
Zouman, Abdulrahman
Arfin, Misbahul
Tariq, Mohammad
Al-Asmari, Abdulrahaman
author_facet Al Harthi, Fahad
Huraib, Ghaleb Bin
Zouman, Abdulrahman
Arfin, Misbahul
Tariq, Mohammad
Al-Asmari, Abdulrahaman
author_sort Al Harthi, Fahad
collection PubMed
description Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. Results. The frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls. The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients. Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE ε4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides. Conclusion. APOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.
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spelling pubmed-39810092014-04-29 Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis Al Harthi, Fahad Huraib, Ghaleb Bin Zouman, Abdulrahman Arfin, Misbahul Tariq, Mohammad Al-Asmari, Abdulrahaman Dis Markers Research Article Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. Results. The frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls. The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients. Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE ε4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides. Conclusion. APOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients. Hindawi Publishing Corporation 2014 2014-03-23 /pmc/articles/PMC3981009/ /pubmed/24782577 http://dx.doi.org/10.1155/2014/239645 Text en Copyright © 2014 Fahad Al Harthi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al Harthi, Fahad
Huraib, Ghaleb Bin
Zouman, Abdulrahman
Arfin, Misbahul
Tariq, Mohammad
Al-Asmari, Abdulrahaman
Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title_full Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title_fullStr Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title_full_unstemmed Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title_short Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
title_sort apolipoprotein e gene polymorphism and serum lipid profile in saudi patients with psoriasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981009/
https://www.ncbi.nlm.nih.gov/pubmed/24782577
http://dx.doi.org/10.1155/2014/239645
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