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The evolution of bacterial social life: From the ivory tower to the front lines of public health

Drug-resistant bacteria are a huge and growing threat to public health. A solution exists in theory, but had not yet been put to a practical test. The accompanying paper by Ross-Gillespie et al., the theory is put to a test and performs successfully. As predicted, using a drug that targets bacteria&...

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Autor principal: Pepper, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981165/
https://www.ncbi.nlm.nih.gov/pubmed/24627463
http://dx.doi.org/10.1093/emph/eou010
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description Drug-resistant bacteria are a huge and growing threat to public health. A solution exists in theory, but had not yet been put to a practical test. The accompanying paper by Ross-Gillespie et al., the theory is put to a test and performs successfully. As predicted, using a drug that targets bacteria's shared secreted ‘public goods’ molecules instead of cell components did not drive the bacterial evolution of drug resistance, and therefore retained its effectiveness. This result holds great promise for better drugs and vaccines against many infectious diseases, and also for better cancer therapies.
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spelling pubmed-39811652015-01-01 The evolution of bacterial social life: From the ivory tower to the front lines of public health Pepper, John W. Evol Med Public Health Interpretive Essay Drug-resistant bacteria are a huge and growing threat to public health. A solution exists in theory, but had not yet been put to a practical test. The accompanying paper by Ross-Gillespie et al., the theory is put to a test and performs successfully. As predicted, using a drug that targets bacteria's shared secreted ‘public goods’ molecules instead of cell components did not drive the bacterial evolution of drug resistance, and therefore retained its effectiveness. This result holds great promise for better drugs and vaccines against many infectious diseases, and also for better cancer therapies. Oxford University Press 2014-04-08 /pmc/articles/PMC3981165/ /pubmed/24627463 http://dx.doi.org/10.1093/emph/eou010 Text en Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health 2014. This work is written by a US Government employee and is in the public domain in the US.
spellingShingle Interpretive Essay
Pepper, John W.
The evolution of bacterial social life: From the ivory tower to the front lines of public health
title The evolution of bacterial social life: From the ivory tower to the front lines of public health
title_full The evolution of bacterial social life: From the ivory tower to the front lines of public health
title_fullStr The evolution of bacterial social life: From the ivory tower to the front lines of public health
title_full_unstemmed The evolution of bacterial social life: From the ivory tower to the front lines of public health
title_short The evolution of bacterial social life: From the ivory tower to the front lines of public health
title_sort evolution of bacterial social life: from the ivory tower to the front lines of public health
topic Interpretive Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981165/
https://www.ncbi.nlm.nih.gov/pubmed/24627463
http://dx.doi.org/10.1093/emph/eou010
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