Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype

T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4(+), CD4(−), CD8(−), CD4(+), CD8(+) cases have been described. The disease is usually characterized by cytopenias and a modest lymphoc...

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Detalles Bibliográficos
Autores principales: Petsa, Panagiota K., Karamoutsios, Achilleas, Dova, Lefkothea, Benetatos, Leonidas, Petsiou, Asimina, Kolaitis, Nikolaos, Georgopoulos, Antonis, Vartholomatos, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981314/
https://www.ncbi.nlm.nih.gov/pubmed/24765467
http://dx.doi.org/10.4081/cp.2012.e68
Descripción
Sumario:T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4(+), CD4(−), CD8(−), CD4(+), CD8(+) cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The majority of patients with T-LGL leukemia remains asymptomatic for a long period and will require treatment later during the course of their disease. Hereby we describe a case of T-LGL leukemia diagnosed by flow cytometry, which presented indolent course and required no treatment so far.

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