Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding pr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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PAGEPress Publications
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981359/ https://www.ncbi.nlm.nih.gov/pubmed/24765339 http://dx.doi.org/10.4081/cp.2011.e78 |
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author | Kinoshita, Hiroyuki Ishii, Amiko Hayakawa, Akiko Yasuda, Mutsuko Inoshita, Seiji Yakushiji, Fumiatsu |
author_facet | Kinoshita, Hiroyuki Ishii, Amiko Hayakawa, Akiko Yasuda, Mutsuko Inoshita, Seiji Yakushiji, Fumiatsu |
author_sort | Kinoshita, Hiroyuki |
collection | PubMed |
description | We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30–50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30–50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism. |
format | Online Article Text |
id | pubmed-3981359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-39813592014-04-24 Severe hypothyroidism associated with the degree of edema in a patient with nephrosis Kinoshita, Hiroyuki Ishii, Amiko Hayakawa, Akiko Yasuda, Mutsuko Inoshita, Seiji Yakushiji, Fumiatsu Clin Pract Case Report We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30–50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30–50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism. PAGEPress Publications 2011-10-13 /pmc/articles/PMC3981359/ /pubmed/24765339 http://dx.doi.org/10.4081/cp.2011.e78 Text en ©Copyright H. Kinoshita et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Case Report Kinoshita, Hiroyuki Ishii, Amiko Hayakawa, Akiko Yasuda, Mutsuko Inoshita, Seiji Yakushiji, Fumiatsu Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title | Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title_full | Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title_fullStr | Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title_full_unstemmed | Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title_short | Severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
title_sort | severe hypothyroidism associated with the degree of edema in a patient with nephrosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981359/ https://www.ncbi.nlm.nih.gov/pubmed/24765339 http://dx.doi.org/10.4081/cp.2011.e78 |
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