Severe hypothyroidism associated with the degree of edema in a patient with nephrosis

We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding pr...

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Autores principales: Kinoshita, Hiroyuki, Ishii, Amiko, Hayakawa, Akiko, Yasuda, Mutsuko, Inoshita, Seiji, Yakushiji, Fumiatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981359/
https://www.ncbi.nlm.nih.gov/pubmed/24765339
http://dx.doi.org/10.4081/cp.2011.e78
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author Kinoshita, Hiroyuki
Ishii, Amiko
Hayakawa, Akiko
Yasuda, Mutsuko
Inoshita, Seiji
Yakushiji, Fumiatsu
author_facet Kinoshita, Hiroyuki
Ishii, Amiko
Hayakawa, Akiko
Yasuda, Mutsuko
Inoshita, Seiji
Yakushiji, Fumiatsu
author_sort Kinoshita, Hiroyuki
collection PubMed
description We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30–50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30–50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism.
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spelling pubmed-39813592014-04-24 Severe hypothyroidism associated with the degree of edema in a patient with nephrosis Kinoshita, Hiroyuki Ishii, Amiko Hayakawa, Akiko Yasuda, Mutsuko Inoshita, Seiji Yakushiji, Fumiatsu Clin Pract Case Report We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30–50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30–50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism. PAGEPress Publications 2011-10-13 /pmc/articles/PMC3981359/ /pubmed/24765339 http://dx.doi.org/10.4081/cp.2011.e78 Text en ©Copyright H. Kinoshita et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Kinoshita, Hiroyuki
Ishii, Amiko
Hayakawa, Akiko
Yasuda, Mutsuko
Inoshita, Seiji
Yakushiji, Fumiatsu
Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title_full Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title_fullStr Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title_full_unstemmed Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title_short Severe hypothyroidism associated with the degree of edema in a patient with nephrosis
title_sort severe hypothyroidism associated with the degree of edema in a patient with nephrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981359/
https://www.ncbi.nlm.nih.gov/pubmed/24765339
http://dx.doi.org/10.4081/cp.2011.e78
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