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Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases

The incidence of myositis in patients with systemic lupus erythematosus (SLE) is low among different series. Here we attempt to describe the main features of SLE/myositis overlap syndrome. We retrospectively reviewed the medical records of 174 patients with SLE seen over 15-year period. All the pati...

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Autores principales: Maazoun, Fatma, Frikha, Faten, Snoussi, Mouna, Kaddour, Neila, Masmoudi, Hatem, Bahloul, Zouhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981442/
https://www.ncbi.nlm.nih.gov/pubmed/24765389
http://dx.doi.org/10.4081/cp.2011.e89
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author Maazoun, Fatma
Frikha, Faten
Snoussi, Mouna
Kaddour, Neila
Masmoudi, Hatem
Bahloul, Zouhir
author_facet Maazoun, Fatma
Frikha, Faten
Snoussi, Mouna
Kaddour, Neila
Masmoudi, Hatem
Bahloul, Zouhir
author_sort Maazoun, Fatma
collection PubMed
description The incidence of myositis in patients with systemic lupus erythematosus (SLE) is low among different series. Here we attempt to describe the main features of SLE/myositis overlap syndrome. We retrospectively reviewed the medical records of 174 patients with SLE seen over 15-year period. All the patients fulfilled the revised American Rheumatology Association criteria for SLE. Patients who met The Bohan and Peter criteria for definite myositis were included in this study. Among those patients, six patients had an associated myositis (3.4% overall). They were 6 women with a mean age of 29 years (20–41 years). At the initial evaluation, 3 patients (50%) were complained from myalgia, and all patients had symmetrical muscle weakness (proximal muscle weakness in 6 cases with distal muscle weakness in 2 cases). The muscle disease was severe in 1 case. Involvements of muscles of the pharynx and upper esophagus were noted in 4 patients (66.6%). The creatine kinase (CK) levels were elevated in 4 cases with a mean rate of 2153.5 UI/L. The electromyogram (EMG) revealed signs of myositis in 5 cases. Muscle biopsy, performed in 5 patients, revealed an inflammatory myopathy changes in 4 cases. Antinuclear antibodies (ANA) were positive in all cases. All our patients were treated with high doses of corticosteroids with favorable outcome. Relapse of SLE disease had occurred in 2 patients. The association SLE-myositis is rare with heterogeneous presentation. Through our observations and literature data we will specify the characteristics of this association.
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spelling pubmed-39814422014-04-24 Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases Maazoun, Fatma Frikha, Faten Snoussi, Mouna Kaddour, Neila Masmoudi, Hatem Bahloul, Zouhir Clin Pract Article The incidence of myositis in patients with systemic lupus erythematosus (SLE) is low among different series. Here we attempt to describe the main features of SLE/myositis overlap syndrome. We retrospectively reviewed the medical records of 174 patients with SLE seen over 15-year period. All the patients fulfilled the revised American Rheumatology Association criteria for SLE. Patients who met The Bohan and Peter criteria for definite myositis were included in this study. Among those patients, six patients had an associated myositis (3.4% overall). They were 6 women with a mean age of 29 years (20–41 years). At the initial evaluation, 3 patients (50%) were complained from myalgia, and all patients had symmetrical muscle weakness (proximal muscle weakness in 6 cases with distal muscle weakness in 2 cases). The muscle disease was severe in 1 case. Involvements of muscles of the pharynx and upper esophagus were noted in 4 patients (66.6%). The creatine kinase (CK) levels were elevated in 4 cases with a mean rate of 2153.5 UI/L. The electromyogram (EMG) revealed signs of myositis in 5 cases. Muscle biopsy, performed in 5 patients, revealed an inflammatory myopathy changes in 4 cases. Antinuclear antibodies (ANA) were positive in all cases. All our patients were treated with high doses of corticosteroids with favorable outcome. Relapse of SLE disease had occurred in 2 patients. The association SLE-myositis is rare with heterogeneous presentation. Through our observations and literature data we will specify the characteristics of this association. PAGEPress Publications 2011-11-02 /pmc/articles/PMC3981442/ /pubmed/24765389 http://dx.doi.org/10.4081/cp.2011.e89 Text en ©Copyright F. Maazoun et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Article
Maazoun, Fatma
Frikha, Faten
Snoussi, Mouna
Kaddour, Neila
Masmoudi, Hatem
Bahloul, Zouhir
Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title_full Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title_fullStr Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title_full_unstemmed Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title_short Systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
title_sort systemic lupus erythematosusmyositis overlap syndrome: report of 6 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981442/
https://www.ncbi.nlm.nih.gov/pubmed/24765389
http://dx.doi.org/10.4081/cp.2011.e89
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