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Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors
DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to activate the human AR, ER, and GR and determine...
Autores principales: | Shaak, Thomas L., Wijesinghe, Dayanjan S., Chalfant, Charles E., Diegelmann, Robert F., Ward, Kevin R., Loria, Roger M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981456/ https://www.ncbi.nlm.nih.gov/pubmed/24729874 http://dx.doi.org/10.1155/2013/203606 |
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