Cargando…

Cytomegalovirus Infection Impairs Immunosuppressive and Antimicrobial Effector Functions of Human Multipotent Mesenchymal Stromal Cells

Human mesenchymal stromal cells (MSC) possess immunosuppressive and antimicrobial effects that are partly mediated by the tryptophan-catabolizing enzyme indoleamine-2,3-dioxygenase (IDO). Therefore MSC represent a promising novel cellular immunosuppressant which has the potential to control steroid-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meisel, Roland, Heseler, Kathrin, Nau, Julia, Schmidt, Silvia Kathrin, Leineweber, Margret, Pudelko, Sabine, Wenning, Johannes, Zimmermann, Albert, Hengel, Hartmut, Sinzger, Christian, Degistirici, Özer, Volker Sorg, Rüdiger, Däubener, Walter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981523/ https://www.ncbi.nlm.nih.gov/pubmed/24782599 http://dx.doi.org/10.1155/2014/898630

Ejemplares similares

Cytomegalovirus Impairs the Induction of Indoleamine 2,3-Dioxygenase Mediated Antimicrobial and Immunoregulatory Effects in Human Fibroblasts
por: Heseler, Kathrin, et al.
Publicado: (2013)

HCMV Infection in a Mesenchymal Stem Cell Niche: Differential Impact on the Development of NK Cells versus ILC3
por: Ising, Ricarda, et al.
Publicado: (2019)

Influence of Tryptophan Contained in 1-Methyl-Tryptophan on Antimicrobial and Immunoregulatory Functions of Indoleamine 2,3-Dioxygenase
por: Schmidt, Silvia K., et al.
Publicado: (2012)

The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects
por: Müller, Anika, et al.
Publicado: (2009)

Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells
por: Walton, Senta M., et al.
Publicado: (2011)

Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis
por: Nau, Julia, et al.
Publicado: (2017)

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
por: Spitzhorn, Lucas-Sebastian, et al.
Publicado: (2019)

Human Cytomegalovirus and Autoimmune Disease
por: Halenius, Anne, et al.
Publicado: (2014)

First Characterization of the Neospora caninum Dense Granule Protein GRA9
por: Leineweber, Margret, et al.
Publicado: (2017)

The relationship of immunosuppression to cytomegalovirus infection.
por: Dowling, J. N., et al.
Publicado: (1976)

Impact of human mesenchymal stromal cells on antifungal host response against Aspergillus fumigatus
por: Schmidt, Stanislaw, et al.
Publicado: (2017)

Transmission of cell-associated human cytomegalovirus isolates between various cell types using polymorphonuclear leukocytes as a vehicle
por: Braun, Berenike, et al.
Publicado: (2021)

Highly individual patterns of virus-immune IgG effector responses in humans
por: Corrales-Aguilar, Eugenia, et al.
Publicado: (2016)

Identification of DNA-Damage DNA-Binding Protein 1 as a Conditional Essential Factor for Cytomegalovirus Replication in Interferon-γ-Stimulated Cells
por: Trilling, Mirko, et al.
Publicado: (2011)

Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets—but how many arrows in the quiver?
por: Halenius, Anne, et al.
Publicado: (2015)

The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitro
por: Vogeley, Christian, et al.
Publicado: (2021)

Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRα-Derived Entry Inhibitors
por: Laib Sampaio, Kerstin, et al.
Publicado: (2021)

Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants
por: Navaratnarajah, Tharsini, et al.
Publicado: (2022)

Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes
por: Braun, Berenike, et al.
Publicado: (2022)

Cytomegalovirus infection in immunosuppressed patients after kidney transplantation
por: LUSCALOV, SIMONA, et al.
Publicado: (2016)

Severe Cytomegalovirus Gastritis During Natalizumab-Mediated Immunosuppression
por: Persaud, Stephen P., et al.
Publicado: (2017)

Cutaneous Coinfection of Cytomegalovirus and Mycobacterium chelonae Accelerated by Immunosuppression
por: Tsutsumi, Yutaka, et al.
Publicado: (2021)

HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11
por: Zimmermann, Cosima, et al.
Publicado: (2019)

Cytomegalovirus infection and progressive differentiation of effector-memory T cells
por: Pardieck, Iris N., et al.
Publicado: (2018)

Efficient In Vitro Generation of IL-22-Secreting ILC3 From CD34(+) Hematopoietic Progenitors in a Human Mesenchymal Stem Cell Niche
por: Bennstein, Sabrina B., et al.
Publicado: (2021)

Corrigendum: Efficient in vitro generation of IL-22-secreting ILC3 from CD34+ hematopoietic progenitors in a human mesenchymal stem cell niche
por: Bennstein, Sabrina B., et al.
Publicado: (2023)

Basic Biology and Clinical Application of Multipotent Mesenchymal Stromal Cells: From Bench to Bedside
por: Kuçi, Selim, et al.
Publicado: (2012)

The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells
por: Gu, Yuting, et al.
Publicado: (2018)

Indoleamine 2,3-Dioxygenase Activity During Acute Toxoplasmosis and the Suppressed T Cell Proliferation in Mice
por: Ufermann, Christoph-Martin, et al.
Publicado: (2019)

Detection of antibody-secreting cells specific for the cytomegalovirus and herpes simplex virus surface antigens
por: Alt, Mira, et al.
Publicado: (2018)

Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6)
por: Fiebig, Uwe, et al.
Publicado: (2017)

Cytomegalovirus pneumonia in an immunosuppressed sarcoidosis patient; a rare case of cytomegalovirus infection in a sarcoidosis patient
por: Mozdourian, Mahnaz, et al.
Publicado: (2021)

Cytomegalovirus proctitis as a complication of COVID-19 with immunosuppressive treatments
por: Maillet, François, et al.
Publicado: (2021)

Immunosuppressants: COVID-19 and cytomegalovirus reactivation: 2 case reports
Publicado: (2021)

COVID-19 pneumonia, immunosuppression, and cytomegalovirus activation: A perspective
por: Ghosh, K
Publicado: (2021)

hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye
por: Spekker-Bosker, Katrin, et al.
Publicado: (2019)

Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
por: Polić, Bojan, et al.
Publicado: (1998)

Role of Envelope Glycoprotein Complexes in Cell-Associated Spread of Human Cytomegalovirus
por: Weiler, Nina, et al.
Publicado: (2021)

Immunosuppressive peptides and their therapeutic applications()
por: Thell, Kathrin, et al.
Publicado: (2014)

The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression
por: Laib Sampaio, Kerstin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nte84q8pdt47n3eqobegnmla3v