Cargando…

The need for a cultural shift from two-arm to multi-arm RCTS

Detalles Bibliográficos
Autores principales:	Sydes, Matthew R, Parmar, Mahesh KB
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Oral Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981643/ http://dx.doi.org/10.1186/1745-6215-14-S1-O3

Ejemplares similares

Flexible trial design in practice – dropping and adding arms in STAMPEDE: a multi-arm multi-stage randomised controlled trial
por: Sydes, Matthew R, et al.
Publicado: (2011)

A multi-arm multi-stage design for binary outcomes and application to tuberculosis
por: Bratton, Daniel, et al.
Publicado: (2013)

Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
por: Choodari-Oskooei, Babak, et al.
Publicado: (2013)

Treatment selection in multi-arm, multi-stage clinical trials
por: Jaki, Thomas, et al.
Publicado: (2013)

Optimal design for multi-arm multi-stage clinical trials
por: Wason, James MS, et al.
Publicado: (2011)

A framework for the design and analysis of phase III randomised trials in uncommon diseases
por: Parmar, Mahesh, et al.
Publicado: (2015)

Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings
por: Noor, Nurulamin M., et al.
Publicado: (2020)

The value of evidence synthesis in randomised controlled trial (RCT) design, conduct and analysis: MRC clinical trials unit (CTU) at UCL experience
por: Tierney, Jayne F, et al.
Publicado: (2015)

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial
por: Sydes, Matthew R, et al.
Publicado: (2012)

Adding new experimental arms to randomised clinical trials: Impact on error rates
por: Choodari-Oskooei, Babak, et al.
Publicado: (2020)

Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial
por: Sydes, Matthew R, et al.
Publicado: (2009)

A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis
por: Bratton, Daniel J, et al.
Publicado: (2013)

Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework
por: Blenkinsop, Alexandra, et al.
Publicado: (2019)

Methods for standardising and monitoring surgical interventions in RCTs
por: Blencowe, Natalie, et al.
Publicado: (2015)

Beyond total treatment effects in RCTs: why we need to measure outcomes at baseline when investigating mediation
por: Landau, Sabine, et al.
Publicado: (2015)

Exploring challenges of RCTs in the emergency and critical care setting
por: Mouncey, Paul, et al.
Publicado: (2015)

A new measure of predictive ability for survival models
por: Choodari-Oskooei, Babak, et al.
Publicado: (2011)

The design of a multi-arm multi-stage (MAMS) phase III randomised controlled trial comparing alternative regimens for escalating (COMPARE) treatment of intermediate and high-risk oropharyngeal cancer with reflections on the complications of introducing a new experimental ARM
por: Gaunt, Piers, et al.
Publicado: (2015)

Methodological, planning and implementation challenges for rcts evaluating group interventions
por: Hind, Daniel, et al.
Publicado: (2013)

Barriers to blinding: an analysis of the feasibility of blinding in test-treatment RCTS
por: di Ruffano, Lavinia Ferrante, et al.
Publicado: (2015)

Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
por: Choodari-Oskooei, Babak, et al.
Publicado: (2013)

Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform
por: Gilson, C., et al.
Publicado: (2017)

Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial
por: Choodari-Oskooei, Babak, et al.
Publicado: (2023)

Loss of outer arm dynein components produce specific and separable phenotypes in zebrafish
por: Burdine, R, et al.
Publicado: (2012)

Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials
por: Noor, Nurulamin M, et al.
Publicado: (2022)

Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson’s Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer
por: Zeissler, Marie-Louise, et al.
Publicado: (2020)

Comparison of a frequentist and Bayesian response-adaptive randomisation approach in multi-stage phase II selection trials with multiple experimental arms
por: Yap, Christina, et al.
Publicado: (2015)

Can we implement findings from RCTs of diagnostic tests? A review of reporting of test-treat interventions
por: di Ruffano, Lavinia Ferrante, et al.
Publicado: (2015)

P281 Healthy adult with arm swelling and new onset burning pain
por: Shah, Kinjal, et al.
Publicado: (2022)

Accounting for intervention complexity in rcts in surgery: new approaches for intervention definition and methods for monitoring fidelity
por: Blencowe, Natalie, et al.
Publicado: (2013)

“It's what we call a randomised control trial” exploring how randomisation is presented by recruiters in RCTs
por: Jepson, Marcus, et al.
Publicado: (2015)

Researchers' experiences of optimising complex health interventions before full-scale RCTs: results from an exploratory multiple case study
por: Levati, Sara, et al.
Publicado: (2015)

Arm positioning and postural sagittal variation: are kyphosis and lordosis measurements using x-ray reliable?
por: Negrini, S, et al.
Publicado: (2009)

Novel genetic defects in primary ciliary dyskinesia affecting function of dynein arms and central pair apparatus
por: Omran, H
Publicado: (2012)

How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials
por: Barthel, FM-S, et al.
Publicado: (2009)

Analysis of survival data from trials with non-proportional hazards: an empirical comparison of methods
por: Royston, Patrick, et al.
Publicado: (2013)

What does a good RCT recruitment consultation look like? A new simple six-step model to promote information sharing and recruitment to RCTs
por: Realpe, Alba, et al.
Publicado: (2015)

Test-retest standard error of measurements for full-torso surface topography parameters obtained with the arms at 30 and 90 degrees of elevation in healthy teenagers
por: Watkins, E, et al.
Publicado: (2010)

The primary outcomes and power calculations in clinical RCTs in urogynecology - need for improvement?
por: Koch, Marianne, et al.
Publicado: (2015)

Assessing and improving the reliability of meta-analyses of hazard ratios derived from published time-to-event data
por: Tierney, Jayne, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tgjfhfcr8b5vhac4h204f39r7t