Expression of Murine 5-Aminolevulinate Synthase Variants Causes Protoporphyrin IX Accumulation and Light-Induced Mammalian Cell Death

5-Aminolevulinate synthase (ALAS; EC 2.3.1.37) catalyzes the first committed step of heme biosynthesis in animals. The erythroid-specific ALAS isozyme (ALAS2) is negatively regulated by heme at the level of mitochondrial import and, in its mature form, certain mutations of the murine ALAS2 active si...

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Detalles Bibliográficos
Autores principales: Fratz, Erica J., Hunter, Gregory A., Ferreira, Gloria C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981678/
https://www.ncbi.nlm.nih.gov/pubmed/24718052
http://dx.doi.org/10.1371/journal.pone.0093078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981678/
https://www.ncbi.nlm.nih.gov/pubmed/24718052
http://dx.doi.org/10.1371/journal.pone.0093078

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