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Targeting Class I(A) PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma

The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K isoforms as a novel anti-tumor approach i...

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Detalles Bibliográficos
Autores principales:	Höland, Katrin, Boller, Danielle, Hagel, Christian, Dolski, Silvia, Treszl, András, Pardo, Olivier E., Ćwiek, Paulina, Salm, Fabiana, Leni, Zaira, Shepherd, Peter R., Styp-Rekowska, Beata, Djonov, Valentin, von Bueren, André O., Frei, Karl, Arcaro, Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981776/ https://www.ncbi.nlm.nih.gov/pubmed/24718026 http://dx.doi.org/10.1371/journal.pone.0094132

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