Dasatinib Targets B-Lineage Cells but Does Not Provide an Effective Therapy for Myeloproliferative Disease in c-Cbl RING Finger Mutant Mice

This study aimed to determine whether the multi-kinase inhibitor dasatinib would provide an effective therapy for myeloproliferative diseases (MPDs) involving c-Cbl mutations. These mutations, which occur in the RING finger and linker domains, abolish the ability of c-Cbl to function as an E3 ubiqui...

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Detalles Bibliográficos
Autores principales: Duyvestyn, Johanna M., Taylor, Samuel J., Dagger, Samantha A., Orandle, Marlene, Morse, Herbert C., Thien, Christine B. F., Langdon, Wallace Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981816/
https://www.ncbi.nlm.nih.gov/pubmed/24718698
http://dx.doi.org/10.1371/journal.pone.0094717

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