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PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN
Age, sex, hypertension and dietary sodium are proposed to affect plasma and urinary catecholamines. Yet no prior study has examined the simultaneous effects of these factors within the same study population, so results may have been confounded by factors not determined. We investigate, for the first...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981971/ https://www.ncbi.nlm.nih.gov/pubmed/24226101 http://dx.doi.org/10.1038/jhh.2013.112 |
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author | Saxena, Aditi R. Chamarthi, Bindu Williams, Gordon H. Hopkins, Paul N. Seely, Ellen W. |
author_facet | Saxena, Aditi R. Chamarthi, Bindu Williams, Gordon H. Hopkins, Paul N. Seely, Ellen W. |
author_sort | Saxena, Aditi R. |
collection | PubMed |
description | Age, sex, hypertension and dietary sodium are proposed to affect plasma and urinary catecholamines. Yet no prior study has examined the simultaneous effects of these factors within the same study population, so results may have been confounded by factors not determined. We investigate, for the first time, the impact of simultaneously determined predictors of plasma and urinary catecholamines, and the relationship of catecholamines with the diagnosis of hypertension. Hypertensive and normotensive subjects (n=308) were studied off antihypertensives in liberal and low sodium balance. Twenty-four hour urinary catecholamines (norepinephrine and epinephrine) were measured. Plasma catecholamines were measured supine after overnight fast. Repeated measures multivariate linear regression models examined effect of sex, race, age, body mass index, dietary salt (liberal salt vs. low salt), hypertension status, and mean arterial pressure on plasma and urinary catecholamines. Logistic regression determined the relationship of catecholamines with diagnosis of hypertension. Dietary sodium restriction and increasing age predicted increased plasma and urinary norepinephrine, with sodium restriction having greatest effect. Female sex predicted lower urinary and plasma epinephrine. Neither plasma nor urinary catecholamines predicted the diagnosis of hypertension. In summary, specific demographic factors variably impact catecholamines and should be considered when assessing catecholamines in research and clinical settings. |
format | Online Article Text |
id | pubmed-3981971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-39819712014-11-01 PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN Saxena, Aditi R. Chamarthi, Bindu Williams, Gordon H. Hopkins, Paul N. Seely, Ellen W. J Hum Hypertens Article Age, sex, hypertension and dietary sodium are proposed to affect plasma and urinary catecholamines. Yet no prior study has examined the simultaneous effects of these factors within the same study population, so results may have been confounded by factors not determined. We investigate, for the first time, the impact of simultaneously determined predictors of plasma and urinary catecholamines, and the relationship of catecholamines with the diagnosis of hypertension. Hypertensive and normotensive subjects (n=308) were studied off antihypertensives in liberal and low sodium balance. Twenty-four hour urinary catecholamines (norepinephrine and epinephrine) were measured. Plasma catecholamines were measured supine after overnight fast. Repeated measures multivariate linear regression models examined effect of sex, race, age, body mass index, dietary salt (liberal salt vs. low salt), hypertension status, and mean arterial pressure on plasma and urinary catecholamines. Logistic regression determined the relationship of catecholamines with diagnosis of hypertension. Dietary sodium restriction and increasing age predicted increased plasma and urinary norepinephrine, with sodium restriction having greatest effect. Female sex predicted lower urinary and plasma epinephrine. Neither plasma nor urinary catecholamines predicted the diagnosis of hypertension. In summary, specific demographic factors variably impact catecholamines and should be considered when assessing catecholamines in research and clinical settings. 2013-11-14 2014-05 /pmc/articles/PMC3981971/ /pubmed/24226101 http://dx.doi.org/10.1038/jhh.2013.112 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Saxena, Aditi R. Chamarthi, Bindu Williams, Gordon H. Hopkins, Paul N. Seely, Ellen W. PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title | PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title_full | PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title_fullStr | PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title_full_unstemmed | PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title_short | PREDICTORS OF PLASMA AND URINARY CATECHOLAMINE LEVELS IN NORMOTENSIVE AND HYPERTENSIVE MEN AND WOMEN |
title_sort | predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981971/ https://www.ncbi.nlm.nih.gov/pubmed/24226101 http://dx.doi.org/10.1038/jhh.2013.112 |
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