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Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of MSC immunomodulatory function. This effect depends on signaling...

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Detalles Bibliográficos
Autores principales:	Ankrum, James A., Dastidar, Riddhi G., Ong, Joon Faii, Levy, Oren, Karp, Jeffrey M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982175/ https://www.ncbi.nlm.nih.gov/pubmed/24717973 http://dx.doi.org/10.1038/srep04645

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