Cargando…
Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 g...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982207/ https://www.ncbi.nlm.nih.gov/pubmed/24068523 http://dx.doi.org/10.1007/s12013-013-9767-5 |
_version_ | 1782311151835545600 |
---|---|
author | Jiang, Xingliang Li, Min Yang, Qibin Du, Lijun Du, Juan Zhou, Jingguo |
author_facet | Jiang, Xingliang Li, Min Yang, Qibin Du, Lijun Du, Juan Zhou, Jingguo |
author_sort | Jiang, Xingliang |
collection | PubMed |
description | To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 gout patients [28 in acute phase episode, 13 in intermittent phase (IP)], and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-α were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls (P < 0.05), but the levels of TGF-β were significantly lower in the acute phase group than in the IP group and healthy controls (P < 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls (P < 0.05). Correlation analysis indicated that the levels of ox-LDL were positively correlated with hs-CRP, IL-6 and TNF-α (r = 0.343, r = 0.386, r = 0.659, P < 0.01, respectively), but negatively correlated with TGF-β levels in patients in the acute phase (r = −0.240, P < 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients. |
format | Online Article Text |
id | pubmed-3982207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-39822072014-04-23 Oxidized Low Density Lipoprotein and Inflammation in Gout Patients Jiang, Xingliang Li, Min Yang, Qibin Du, Lijun Du, Juan Zhou, Jingguo Cell Biochem Biophys Original Paper To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 gout patients [28 in acute phase episode, 13 in intermittent phase (IP)], and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-α were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls (P < 0.05), but the levels of TGF-β were significantly lower in the acute phase group than in the IP group and healthy controls (P < 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls (P < 0.05). Correlation analysis indicated that the levels of ox-LDL were positively correlated with hs-CRP, IL-6 and TNF-α (r = 0.343, r = 0.386, r = 0.659, P < 0.01, respectively), but negatively correlated with TGF-β levels in patients in the acute phase (r = −0.240, P < 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients. Springer US 2013-09-26 2014 /pmc/articles/PMC3982207/ /pubmed/24068523 http://dx.doi.org/10.1007/s12013-013-9767-5 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Paper Jiang, Xingliang Li, Min Yang, Qibin Du, Lijun Du, Juan Zhou, Jingguo Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title | Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title_full | Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title_fullStr | Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title_full_unstemmed | Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title_short | Oxidized Low Density Lipoprotein and Inflammation in Gout Patients |
title_sort | oxidized low density lipoprotein and inflammation in gout patients |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982207/ https://www.ncbi.nlm.nih.gov/pubmed/24068523 http://dx.doi.org/10.1007/s12013-013-9767-5 |
work_keys_str_mv | AT jiangxingliang oxidizedlowdensitylipoproteinandinflammationingoutpatients AT limin oxidizedlowdensitylipoproteinandinflammationingoutpatients AT yangqibin oxidizedlowdensitylipoproteinandinflammationingoutpatients AT dulijun oxidizedlowdensitylipoproteinandinflammationingoutpatients AT dujuan oxidizedlowdensitylipoproteinandinflammationingoutpatients AT zhoujingguo oxidizedlowdensitylipoproteinandinflammationingoutpatients |