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Oxidized Low Density Lipoprotein and Inflammation in Gout Patients

To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 g...

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Autores principales: Jiang, Xingliang, Li, Min, Yang, Qibin, Du, Lijun, Du, Juan, Zhou, Jingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982207/
https://www.ncbi.nlm.nih.gov/pubmed/24068523
http://dx.doi.org/10.1007/s12013-013-9767-5
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author Jiang, Xingliang
Li, Min
Yang, Qibin
Du, Lijun
Du, Juan
Zhou, Jingguo
author_facet Jiang, Xingliang
Li, Min
Yang, Qibin
Du, Lijun
Du, Juan
Zhou, Jingguo
author_sort Jiang, Xingliang
collection PubMed
description To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 gout patients [28 in acute phase episode, 13 in intermittent phase (IP)], and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-α were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls (P < 0.05), but the levels of TGF-β were significantly lower in the acute phase group than in the IP group and healthy controls (P < 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls (P < 0.05). Correlation analysis indicated that the levels of ox-LDL were positively correlated with hs-CRP, IL-6 and TNF-α (r = 0.343, r = 0.386, r = 0.659, P < 0.01, respectively), but negatively correlated with TGF-β levels in patients in the acute phase (r = −0.240, P < 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients.
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spelling pubmed-39822072014-04-23 Oxidized Low Density Lipoprotein and Inflammation in Gout Patients Jiang, Xingliang Li, Min Yang, Qibin Du, Lijun Du, Juan Zhou, Jingguo Cell Biochem Biophys Original Paper To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 gout patients [28 in acute phase episode, 13 in intermittent phase (IP)], and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-α were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls (P < 0.05), but the levels of TGF-β were significantly lower in the acute phase group than in the IP group and healthy controls (P < 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls (P < 0.05). Correlation analysis indicated that the levels of ox-LDL were positively correlated with hs-CRP, IL-6 and TNF-α (r = 0.343, r = 0.386, r = 0.659, P < 0.01, respectively), but negatively correlated with TGF-β levels in patients in the acute phase (r = −0.240, P < 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients. Springer US 2013-09-26 2014 /pmc/articles/PMC3982207/ /pubmed/24068523 http://dx.doi.org/10.1007/s12013-013-9767-5 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Jiang, Xingliang
Li, Min
Yang, Qibin
Du, Lijun
Du, Juan
Zhou, Jingguo
Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title_full Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title_fullStr Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title_full_unstemmed Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title_short Oxidized Low Density Lipoprotein and Inflammation in Gout Patients
title_sort oxidized low density lipoprotein and inflammation in gout patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982207/
https://www.ncbi.nlm.nih.gov/pubmed/24068523
http://dx.doi.org/10.1007/s12013-013-9767-5
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