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The Circadian Clock Gates the Intestinal Stem Cell Regenerative State

The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are...

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Autores principales: Karpowicz, Phillip, Zhang, Yong, Hogenesch, John B., Emery, Patrick, Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982394/
https://www.ncbi.nlm.nih.gov/pubmed/23583176
http://dx.doi.org/10.1016/j.celrep.2013.03.016
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author Karpowicz, Phillip
Zhang, Yong
Hogenesch, John B.
Emery, Patrick
Perrimon, Norbert
author_facet Karpowicz, Phillip
Zhang, Yong
Hogenesch, John B.
Emery, Patrick
Perrimon, Norbert
author_sort Karpowicz, Phillip
collection PubMed
description The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process.
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spelling pubmed-39823942014-04-25 The Circadian Clock Gates the Intestinal Stem Cell Regenerative State Karpowicz, Phillip Zhang, Yong Hogenesch, John B. Emery, Patrick Perrimon, Norbert Cell Rep Article The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process. 2013-04-11 2013-04-25 /pmc/articles/PMC3982394/ /pubmed/23583176 http://dx.doi.org/10.1016/j.celrep.2013.03.016 Text en ©2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Karpowicz, Phillip
Zhang, Yong
Hogenesch, John B.
Emery, Patrick
Perrimon, Norbert
The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title_full The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title_fullStr The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title_full_unstemmed The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title_short The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
title_sort circadian clock gates the intestinal stem cell regenerative state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982394/
https://www.ncbi.nlm.nih.gov/pubmed/23583176
http://dx.doi.org/10.1016/j.celrep.2013.03.016
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