Cargando…
The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982394/ https://www.ncbi.nlm.nih.gov/pubmed/23583176 http://dx.doi.org/10.1016/j.celrep.2013.03.016 |
_version_ | 1782311177982836736 |
---|---|
author | Karpowicz, Phillip Zhang, Yong Hogenesch, John B. Emery, Patrick Perrimon, Norbert |
author_facet | Karpowicz, Phillip Zhang, Yong Hogenesch, John B. Emery, Patrick Perrimon, Norbert |
author_sort | Karpowicz, Phillip |
collection | PubMed |
description | The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process. |
format | Online Article Text |
id | pubmed-3982394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-39823942014-04-25 The Circadian Clock Gates the Intestinal Stem Cell Regenerative State Karpowicz, Phillip Zhang, Yong Hogenesch, John B. Emery, Patrick Perrimon, Norbert Cell Rep Article The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process. 2013-04-11 2013-04-25 /pmc/articles/PMC3982394/ /pubmed/23583176 http://dx.doi.org/10.1016/j.celrep.2013.03.016 Text en ©2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Karpowicz, Phillip Zhang, Yong Hogenesch, John B. Emery, Patrick Perrimon, Norbert The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title | The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title_full | The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title_fullStr | The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title_full_unstemmed | The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title_short | The Circadian Clock Gates the Intestinal Stem Cell Regenerative State |
title_sort | circadian clock gates the intestinal stem cell regenerative state |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982394/ https://www.ncbi.nlm.nih.gov/pubmed/23583176 http://dx.doi.org/10.1016/j.celrep.2013.03.016 |
work_keys_str_mv | AT karpowiczphillip thecircadianclockgatestheintestinalstemcellregenerativestate AT zhangyong thecircadianclockgatestheintestinalstemcellregenerativestate AT hogeneschjohnb thecircadianclockgatestheintestinalstemcellregenerativestate AT emerypatrick thecircadianclockgatestheintestinalstemcellregenerativestate AT perrimonnorbert thecircadianclockgatestheintestinalstemcellregenerativestate AT karpowiczphillip circadianclockgatestheintestinalstemcellregenerativestate AT zhangyong circadianclockgatestheintestinalstemcellregenerativestate AT hogeneschjohnb circadianclockgatestheintestinalstemcellregenerativestate AT emerypatrick circadianclockgatestheintestinalstemcellregenerativestate AT perrimonnorbert circadianclockgatestheintestinalstemcellregenerativestate |