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Cysteine protease inhibition by nitrile-based inhibitors: a computational study

Cysteine protease enzymes are important for human physiology and catalyze key protein degradation pathways. These enzymes react via a nucleophilic reaction mechanism that involves a cysteine residue and the proton of a proximal histidine. Particularly efficient inhibitors of these enzymes are nitril...

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Detalles Bibliográficos
Autores principales:	Quesne, Matthew G., Ward, Richard A., de Visser, Sam P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982517/ https://www.ncbi.nlm.nih.gov/pubmed/24790966 http://dx.doi.org/10.3389/fchem.2013.00039

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