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Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well...

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Detalles Bibliográficos
Autores principales: Hanif, Muhammad, Meier, Samuel M., Nazarov, Alexey A., Risse, Julie, Legin, Anton, Casini, Angela, Jakupec, Michael A., Keppler, Bernhard K., Hartinger, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982558/
https://www.ncbi.nlm.nih.gov/pubmed/24790955
http://dx.doi.org/10.3389/fchem.2013.00027
Descripción
Sumario:The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohexylidene-protected carbohydrate is the most cytotoxic with unprecedented IC(50) values for the compound class in three human cancer cell lines. This compound shows reactivity to the DNA model nucleobase 9-ethylguanine, but does not alter the secondary structure of plasmid DNA, indicating that other biological targets are responsible for its cytotoxic effect.