Cargando…
Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents. Its actions are mediated via its cognate G-protein-coupled receptor, RXFP1 although it also “pharmacologically” activates RXFP2, the receptor for the...
Autores principales: | Chan, Linda J., Smith, Craig M., Chua, Berenice E., Lin, Feng, Bathgate, Ross A. D., Separovic, Frances, Gundlach, Andrew L., Hossain, Mohammed Akhter, Wade, John D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982560/ https://www.ncbi.nlm.nih.gov/pubmed/24790958 http://dx.doi.org/10.3389/fchem.2013.00030 |
Ejemplares similares
-
Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
por: Nair, Vinojini B., et al.
Publicado: (2015) -
C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity
por: Shabanpoor, Fazel, et al.
Publicado: (2013) -
Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin
por: Bruell, Shoni, et al.
Publicado: (2017) -
Evolution of the relaxin-like peptide family
por: Wilkinson, Tracey N, et al.
Publicado: (2005) -
Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists
por: Lee, Han Siean, et al.
Publicado: (2020)