Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature

Patients with neurofibromatosis type 1 (NF1) and Costello syndrome Rasopathy have behavioral deficits. In NF1 patients, these may correlate with white matter enlargement and aberrant myelin. To model these features, we induced Nf1 loss or HRas hyperactivation in mouse oligodendrocytes. Enlarged brai...

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Detalles Bibliográficos
Autores principales: Mayes, Debra A., Rizvi, Tilat A., Titus-Mitchell, Haley, Oberst, Rachel, Ciraolo, Georgianne M., Vorhees, Charles V., Robinson, Andrew P., Miller, Stephen D., Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Ratner, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982616/
https://www.ncbi.nlm.nih.gov/pubmed/24035394
http://dx.doi.org/10.1016/j.celrep.2013.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982616/
https://www.ncbi.nlm.nih.gov/pubmed/24035394
http://dx.doi.org/10.1016/j.celrep.2013.08.011

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