Evolving blood pressure dynamics for extremely preterm infants

OBJECTIVE: To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants. STUDY DESIGN: Prospective observational study of infants 23(0/7) – 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 hours. RESUL...

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Detalles Bibliográficos
Autores principales: Batton, Beau, Li, Lei, Newman, Nancy S., Das, Abhik, Watterberg, Kristi L., Yoder, Bradley A., Faix, Roger G., Laughon, Matthew M., Stoll, Barbara J., Higgins, Rosemary D., Walsh, Michele C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982788/
https://www.ncbi.nlm.nih.gov/pubmed/24503912
http://dx.doi.org/10.1038/jp.2014.6
Descripción
Sumario:OBJECTIVE: To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants. STUDY DESIGN: Prospective observational study of infants 23(0/7) – 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 hours. RESULTS: A cohort of 367 infants had 18,709 ABP measurements recorded. ABP decreased for the first three hours, reached a nadir at 4 – 5 hours, then increased at an average rate of 0.2 mmHg / hour. The rise in ABP from hour 4 – 24 was similar for untreated infants (n=164) and infants given any antihypotensive therapy (n=203), a fluid bolus (n=135), or dopamine (n=92). GA specific trends were similar. ABP tended to be lower as GA decreased, but varied widely at each GA. CONCLUSION: Arterial blood pressure increased spontaneously over the first 24 postnatal hours for extremely preterm infants. The rate of rise in ABP did not change with antihypotensive therapy.

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