Age-Related Histological Changes in Kidneys of Brown Norway Rat

In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative sc...

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Detalles Bibliográficos
Autores principales: YABUKI, Akira, YONESHIGE, Shinichiro, TANAKA, Shin, TSUJIO, Masashi, MITANI, Sawane, YAMATO, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2013
Materias:
Anatomy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982817/
https://www.ncbi.nlm.nih.gov/pubmed/24107464
http://dx.doi.org/10.1292/jvms.13-0431
Descripción
Sumario:In this study, age-dependent histological changes in the kidneys of Brown Norway rat, a strain useful for conducting aging research, were evaluated. Examination was performed at 3, 12, 18, 24 and 30 months of age. Sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. A marginal increase in scores was observed for glomerular cystic changes and tubulointerstitial damage. Further, urothelial hyperplasia was observed in the renal papillae, particularly at 30 months of age. In conclusion, the findings of the present study demonstrate that the Brown Norway strain exhibits persistent, but mild progression of age-dependent renal histological changes.

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