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Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys
Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unknown, because of the scarcity of reports involving...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982829/ https://www.ncbi.nlm.nih.gov/pubmed/24132296 http://dx.doi.org/10.1292/jvms.13-0350 |
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author | MASUNO, Koichi FUKUDA, Yasuhiro KUBO, Masahito IKARASHI, Ryo KURAISHI, Takeshi HATTORI, Shosaku KIMURA, Junpei KAI, Chieko YANAI, Tokuma NAKAI, Yutaka |
author_facet | MASUNO, Koichi FUKUDA, Yasuhiro KUBO, Masahito IKARASHI, Ryo KURAISHI, Takeshi HATTORI, Shosaku KIMURA, Junpei KAI, Chieko YANAI, Tokuma NAKAI, Yutaka |
author_sort | MASUNO, Koichi |
collection | PubMed |
description | Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unknown, because of the scarcity of reports involving human infections. To assess the infectivity and the clinical and pathological features of C. andersoni and C. muris in primates, an experimental infectious study was conducted using cynomolgus monkeys. The monkeys were orally inoculated with oocysts of two different C. andersoni Kawatabi types and C. muris RN-66 under normal and immunosuppressive conditions. The feces of the monkeys were monitored for about 40 days after the administration of oocysts using the flotation method, but no shedding oocysts were observed under either both normal or immunosuppressive conditions. Gross and histopathological examinations were performed on the immunosuppressive monkeys, but these revealed no evidence of Cryptosporidium infections, even though the monkeys were subjected to immunosuppressive conditions. It is hypothesized that C. andersoni and C. muris pose little danger of infection in primates even under immunosuppressive conditions. |
format | Online Article Text |
id | pubmed-3982829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39828292014-04-22 Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys MASUNO, Koichi FUKUDA, Yasuhiro KUBO, Masahito IKARASHI, Ryo KURAISHI, Takeshi HATTORI, Shosaku KIMURA, Junpei KAI, Chieko YANAI, Tokuma NAKAI, Yutaka J Vet Med Sci Parasitology Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unknown, because of the scarcity of reports involving human infections. To assess the infectivity and the clinical and pathological features of C. andersoni and C. muris in primates, an experimental infectious study was conducted using cynomolgus monkeys. The monkeys were orally inoculated with oocysts of two different C. andersoni Kawatabi types and C. muris RN-66 under normal and immunosuppressive conditions. The feces of the monkeys were monitored for about 40 days after the administration of oocysts using the flotation method, but no shedding oocysts were observed under either both normal or immunosuppressive conditions. Gross and histopathological examinations were performed on the immunosuppressive monkeys, but these revealed no evidence of Cryptosporidium infections, even though the monkeys were subjected to immunosuppressive conditions. It is hypothesized that C. andersoni and C. muris pose little danger of infection in primates even under immunosuppressive conditions. The Japanese Society of Veterinary Science 2013-10-16 2014-02 /pmc/articles/PMC3982829/ /pubmed/24132296 http://dx.doi.org/10.1292/jvms.13-0350 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Parasitology MASUNO, Koichi FUKUDA, Yasuhiro KUBO, Masahito IKARASHI, Ryo KURAISHI, Takeshi HATTORI, Shosaku KIMURA, Junpei KAI, Chieko YANAI, Tokuma NAKAI, Yutaka Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys |
title | Infectivity of Cryptosporidium andersoni and
Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus
Monkeys |
title_full | Infectivity of Cryptosporidium andersoni and
Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus
Monkeys |
title_fullStr | Infectivity of Cryptosporidium andersoni and
Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus
Monkeys |
title_full_unstemmed | Infectivity of Cryptosporidium andersoni and
Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus
Monkeys |
title_short | Infectivity of Cryptosporidium andersoni and
Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus
Monkeys |
title_sort | infectivity of cryptosporidium andersoni and
cryptosporidium muris to normal and immunosuppressive cynomolgus
monkeys |
topic | Parasitology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982829/ https://www.ncbi.nlm.nih.gov/pubmed/24132296 http://dx.doi.org/10.1292/jvms.13-0350 |
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