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Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia

BACKGROUND: Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and...

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Autores principales: Park, S. Lani, Fesinmeyer, Megan D., Timofeeva, Maria, Caberto, Christian P., Kocarnik, Jonathan M., Han, Younghun, Love, Shelly-Ann, Young, Alicia, Dumitrescu, Logan, Lin, Yi, Goodloe, Robert, Wilkens, Lynne R., Hindorff, Lucia, Fowke, Jay H., Carty, Cara, Buyske, Steven, Schumacher, Frederick R., Butler, Anne, Dilks, Holli, Deelman, Ewa, Cote, Michele L., Chen, Wei, Pande, Mala, Christiani, David C., Field, John K., Bickebӧller, Heike, Risch, Angela, Heinrich, Joachim, Brennan, Paul, Wang, Yufei, Eisen, Timothy, Houlston, Richard S., Thun, Michael, Albanes, Demetrius, Caporaso, Neil, Peters, Ulrike, North, Kari E., Heiss, Gerardo, Crawford, Dana C., Bush, William S., Haiman, Christopher A., Landi, Maria Teresa, Hung, Rayjean J., Kooperberg, Charles, Amos, Christopher I., Le Marchand, Loïc, Cheng, Iona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982896/
https://www.ncbi.nlm.nih.gov/pubmed/24681604
http://dx.doi.org/10.1093/jnci/dju061
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author Park, S. Lani
Fesinmeyer, Megan D.
Timofeeva, Maria
Caberto, Christian P.
Kocarnik, Jonathan M.
Han, Younghun
Love, Shelly-Ann
Young, Alicia
Dumitrescu, Logan
Lin, Yi
Goodloe, Robert
Wilkens, Lynne R.
Hindorff, Lucia
Fowke, Jay H.
Carty, Cara
Buyske, Steven
Schumacher, Frederick R.
Butler, Anne
Dilks, Holli
Deelman, Ewa
Cote, Michele L.
Chen, Wei
Pande, Mala
Christiani, David C.
Field, John K.
Bickebӧller, Heike
Risch, Angela
Heinrich, Joachim
Brennan, Paul
Wang, Yufei
Eisen, Timothy
Houlston, Richard S.
Thun, Michael
Albanes, Demetrius
Caporaso, Neil
Peters, Ulrike
North, Kari E.
Heiss, Gerardo
Crawford, Dana C.
Bush, William S.
Haiman, Christopher A.
Landi, Maria Teresa
Hung, Rayjean J.
Kooperberg, Charles
Amos, Christopher I.
Le Marchand, Loïc
Cheng, Iona
author_facet Park, S. Lani
Fesinmeyer, Megan D.
Timofeeva, Maria
Caberto, Christian P.
Kocarnik, Jonathan M.
Han, Younghun
Love, Shelly-Ann
Young, Alicia
Dumitrescu, Logan
Lin, Yi
Goodloe, Robert
Wilkens, Lynne R.
Hindorff, Lucia
Fowke, Jay H.
Carty, Cara
Buyske, Steven
Schumacher, Frederick R.
Butler, Anne
Dilks, Holli
Deelman, Ewa
Cote, Michele L.
Chen, Wei
Pande, Mala
Christiani, David C.
Field, John K.
Bickebӧller, Heike
Risch, Angela
Heinrich, Joachim
Brennan, Paul
Wang, Yufei
Eisen, Timothy
Houlston, Richard S.
Thun, Michael
Albanes, Demetrius
Caporaso, Neil
Peters, Ulrike
North, Kari E.
Heiss, Gerardo
Crawford, Dana C.
Bush, William S.
Haiman, Christopher A.
Landi, Maria Teresa
Hung, Rayjean J.
Kooperberg, Charles
Amos, Christopher I.
Le Marchand, Loïc
Cheng, Iona
author_sort Park, S. Lani
collection PubMed
description BACKGROUND: Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed. METHODS: We included 18023 patients with lung cancer and 60543 control subjects from two consortia, Population Architecture using Genomics and Epidemiology (PAGE) and Transdisciplinary Research in Cancer of the Lung (TRICL). We examined 165 single-nucleotide polymorphisms (SNPs) that were previously associated with at least one of 16 non–lung cancer sites. Study-specific logistic regression results underwent meta-analysis, and associations were also examined by race/ethnicity, histological cell type, sex, and smoking status. A Bonferroni-corrected P value of 2.5×10(–5) was used to assign statistical significance. RESULTS: The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio [OR] = 1.10; 95% confidence interval [CI] = 1.05 to 1.14; P = 2.8×10(–6)). This association was strongest for women with adenocarcinoma (P = 1.2×10(–4)) and not statistically significant in men (P = .14) with this cell type (P (het by sex) = .10). Two glioma risk variants, TERT rs2853676 and CDKN2BAS1 rs4977756, which are located in regions previously associated with lung cancer, were associated with increased risk of adenocarcinoma (OR = 1.16; 95% CI = 1.10 to 1.22; P = 1.1×10(–8)) and squamous cell carcinoma (OR = 1.13; CI = 1.07 to 1.19; P = 2.5×10(–5)), respectively. CONCLUSIONS: Our findings demonstrate a novel pleiotropic association between the breast cancer LSP1 risk region marked by variant rs3817198 and lung cancer risk.
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spelling pubmed-39828962014-04-10 Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia Park, S. Lani Fesinmeyer, Megan D. Timofeeva, Maria Caberto, Christian P. Kocarnik, Jonathan M. Han, Younghun Love, Shelly-Ann Young, Alicia Dumitrescu, Logan Lin, Yi Goodloe, Robert Wilkens, Lynne R. Hindorff, Lucia Fowke, Jay H. Carty, Cara Buyske, Steven Schumacher, Frederick R. Butler, Anne Dilks, Holli Deelman, Ewa Cote, Michele L. Chen, Wei Pande, Mala Christiani, David C. Field, John K. Bickebӧller, Heike Risch, Angela Heinrich, Joachim Brennan, Paul Wang, Yufei Eisen, Timothy Houlston, Richard S. Thun, Michael Albanes, Demetrius Caporaso, Neil Peters, Ulrike North, Kari E. Heiss, Gerardo Crawford, Dana C. Bush, William S. Haiman, Christopher A. Landi, Maria Teresa Hung, Rayjean J. Kooperberg, Charles Amos, Christopher I. Le Marchand, Loïc Cheng, Iona J Natl Cancer Inst Article BACKGROUND: Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed. METHODS: We included 18023 patients with lung cancer and 60543 control subjects from two consortia, Population Architecture using Genomics and Epidemiology (PAGE) and Transdisciplinary Research in Cancer of the Lung (TRICL). We examined 165 single-nucleotide polymorphisms (SNPs) that were previously associated with at least one of 16 non–lung cancer sites. Study-specific logistic regression results underwent meta-analysis, and associations were also examined by race/ethnicity, histological cell type, sex, and smoking status. A Bonferroni-corrected P value of 2.5×10(–5) was used to assign statistical significance. RESULTS: The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio [OR] = 1.10; 95% confidence interval [CI] = 1.05 to 1.14; P = 2.8×10(–6)). This association was strongest for women with adenocarcinoma (P = 1.2×10(–4)) and not statistically significant in men (P = .14) with this cell type (P (het by sex) = .10). Two glioma risk variants, TERT rs2853676 and CDKN2BAS1 rs4977756, which are located in regions previously associated with lung cancer, were associated with increased risk of adenocarcinoma (OR = 1.16; 95% CI = 1.10 to 1.22; P = 1.1×10(–8)) and squamous cell carcinoma (OR = 1.13; CI = 1.07 to 1.19; P = 2.5×10(–5)), respectively. CONCLUSIONS: Our findings demonstrate a novel pleiotropic association between the breast cancer LSP1 risk region marked by variant rs3817198 and lung cancer risk. Oxford University Press 2014-03-28 /pmc/articles/PMC3982896/ /pubmed/24681604 http://dx.doi.org/10.1093/jnci/dju061 Text en © The Author 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Park, S. Lani
Fesinmeyer, Megan D.
Timofeeva, Maria
Caberto, Christian P.
Kocarnik, Jonathan M.
Han, Younghun
Love, Shelly-Ann
Young, Alicia
Dumitrescu, Logan
Lin, Yi
Goodloe, Robert
Wilkens, Lynne R.
Hindorff, Lucia
Fowke, Jay H.
Carty, Cara
Buyske, Steven
Schumacher, Frederick R.
Butler, Anne
Dilks, Holli
Deelman, Ewa
Cote, Michele L.
Chen, Wei
Pande, Mala
Christiani, David C.
Field, John K.
Bickebӧller, Heike
Risch, Angela
Heinrich, Joachim
Brennan, Paul
Wang, Yufei
Eisen, Timothy
Houlston, Richard S.
Thun, Michael
Albanes, Demetrius
Caporaso, Neil
Peters, Ulrike
North, Kari E.
Heiss, Gerardo
Crawford, Dana C.
Bush, William S.
Haiman, Christopher A.
Landi, Maria Teresa
Hung, Rayjean J.
Kooperberg, Charles
Amos, Christopher I.
Le Marchand, Loïc
Cheng, Iona
Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title_full Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title_fullStr Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title_full_unstemmed Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title_short Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
title_sort pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the page and tricl consortia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982896/
https://www.ncbi.nlm.nih.gov/pubmed/24681604
http://dx.doi.org/10.1093/jnci/dju061
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