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Differential regulation of myosin heavy chains defines new muscle domains in zebrafish

Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell groups. In this study, we show that six fast muscle–specific myosin heavy chain genes have unique expression patterns in the zebrafish embryo. The expression of tail-specific myosin heavy chain (fmyhc2.1)...

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Autores principales: Nord, Hanna, Burguiere, Anne-Cecile, Muck, Joscha, Nord, Christoffer, Ahlgren, Ulf, von Hofsten, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983002/
https://www.ncbi.nlm.nih.gov/pubmed/24523292
http://dx.doi.org/10.1091/mbc.E13-08-0486
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author Nord, Hanna
Burguiere, Anne-Cecile
Muck, Joscha
Nord, Christoffer
Ahlgren, Ulf
von Hofsten, Jonas
author_facet Nord, Hanna
Burguiere, Anne-Cecile
Muck, Joscha
Nord, Christoffer
Ahlgren, Ulf
von Hofsten, Jonas
author_sort Nord, Hanna
collection PubMed
description Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell groups. In this study, we show that six fast muscle–specific myosin heavy chain genes have unique expression patterns in the zebrafish embryo. The expression of tail-specific myosin heavy chain (fmyhc2.1) requires wnt signaling and is essential for fast muscle organization within the tail. Retinoic acid treatment results in reduced wnt signaling, which leads to loss of the fmyhc2.1 domain. Retinoic acid treatment also results in a shift of muscle identity within two trunk domains defined by expression of fmyhc1.2 and fmyhc1.3 in favor of the anteriormost myosin isoform, fmyhc1.2. In summary, we identify new muscle domains along the anteroposterior axis in the zebrafish that are defined by individual nonoverlapping, differentially regulated expression of myosin heavy chain isoforms.
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spelling pubmed-39830022014-06-30 Differential regulation of myosin heavy chains defines new muscle domains in zebrafish Nord, Hanna Burguiere, Anne-Cecile Muck, Joscha Nord, Christoffer Ahlgren, Ulf von Hofsten, Jonas Mol Biol Cell Articles Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell groups. In this study, we show that six fast muscle–specific myosin heavy chain genes have unique expression patterns in the zebrafish embryo. The expression of tail-specific myosin heavy chain (fmyhc2.1) requires wnt signaling and is essential for fast muscle organization within the tail. Retinoic acid treatment results in reduced wnt signaling, which leads to loss of the fmyhc2.1 domain. Retinoic acid treatment also results in a shift of muscle identity within two trunk domains defined by expression of fmyhc1.2 and fmyhc1.3 in favor of the anteriormost myosin isoform, fmyhc1.2. In summary, we identify new muscle domains along the anteroposterior axis in the zebrafish that are defined by individual nonoverlapping, differentially regulated expression of myosin heavy chain isoforms. The American Society for Cell Biology 2014-04-15 /pmc/articles/PMC3983002/ /pubmed/24523292 http://dx.doi.org/10.1091/mbc.E13-08-0486 Text en © 2014 Nord et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
spellingShingle Articles
Nord, Hanna
Burguiere, Anne-Cecile
Muck, Joscha
Nord, Christoffer
Ahlgren, Ulf
von Hofsten, Jonas
Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title_full Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title_fullStr Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title_full_unstemmed Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title_short Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
title_sort differential regulation of myosin heavy chains defines new muscle domains in zebrafish
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983002/
https://www.ncbi.nlm.nih.gov/pubmed/24523292
http://dx.doi.org/10.1091/mbc.E13-08-0486
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