A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity

Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, the regions of interaction and inhibitory mechanisms of many therapeutic candidates have yet to be elucidated. Previous chemical screens identified Daclatasvir (BMS-790052) as a potent...

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Detalles Bibliográficos
Autores principales: Qi, Hangfei, Olson, C. Anders, Wu, Nicholas C., Ke, Ruian, Loverdo, Claude, Chu, Virginia, Truong, Shawna, Remenyi, Roland, Chen, Zugen, Du, Yushen, Su, Sheng-Yao, Al-Mawsawi, Laith Q., Wu, Ting-Ting, Chen, Shu-Hua, Lin, Chung-Yen, Zhong, Weidong, Lloyd-Smith, James O., Sun, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983061/
https://www.ncbi.nlm.nih.gov/pubmed/24722365
http://dx.doi.org/10.1371/journal.ppat.1004064

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