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Insight into the Interactions between Novel Isoquinolin-1,3-Dione Derivatives and Cyclin-Dependent Kinase 4 Combining QSAR and Molecular Docking

Several small-molecule CDK inhibitors have been identified, but none have been approved for clinical use in the past few years. A new series of 4-[(3-hydroxybenzylamino)-methylene]-4H-isoquinoline-1,3-diones were reported as highly potent and selective CDK4 inhibitors. In order to find more potent C...

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Detalles Bibliográficos
Autores principales:	Zheng, Junxia, Kong, Hao, Wilson, James M., Guo, Jialiang, Chang, Yiqun, Yang, Mengjia, Xiao, Gaokeng, Sun, Pinghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983096/ https://www.ncbi.nlm.nih.gov/pubmed/24722522 http://dx.doi.org/10.1371/journal.pone.0093704

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