Site-Specific DNA–Doxorubicin Conjugates Display Enhanced Cytotoxicity to Breast Cancer Cells

[Image: see text] Doxorubicin (Dox) is widely used for breast cancer treatment but causes serious side effects including cardiotoxicity that may adversely impact patient lifespan even if treatment is successful. Herein, we describe selective conjugation of Dox to a single site in a DNA hairpin resul...

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Detalles Bibliográficos
Autores principales: Stuart, Christopher H., Horita, David A., Thomas, Michael J., Salsbury, Freddie R., Lively, Mark O., Gmeiner, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983131/
https://www.ncbi.nlm.nih.gov/pubmed/24450459
http://dx.doi.org/10.1021/bc4005427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983131/
https://www.ncbi.nlm.nih.gov/pubmed/24450459
http://dx.doi.org/10.1021/bc4005427

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