EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment given its potential to specifically target tumor tissue while sparing the normal brain. However, the diffuse and infiltrative na...

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Detalles Bibliográficos
Autores principales: Miao, Hongsheng, Choi, Bryan D., Suryadevara, Carter M., Sanchez-Perez, Luis, Yang, Shicheng, De Leon, Gabriel, Sayour, Elias J., McLendon, Roger, Herndon, James E., Healy, Patrick, Archer, Gary E., Bigner, Darell D., Johnson, Laura A., Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983153/
https://www.ncbi.nlm.nih.gov/pubmed/24722266
http://dx.doi.org/10.1371/journal.pone.0094281

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