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Prediction and Experimental Characterization of nsSNPs Altering Human PDZ-Binding Motifs

Single nucleotide polymorphisms (SNPs) are a major contributor to genetic and phenotypic variation within populations. Non-synonymous SNPs (nsSNPs) modify the sequence of proteins and can affect their folding or binding properties. Experimental analysis of all nsSNPs is currently unfeasible and ther...

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Detalles Bibliográficos
Autores principales: Gfeller, David, Ernst, Andreas, Jarvik, Nick, Sidhu, Sachdev S., Bader, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983204/
https://www.ncbi.nlm.nih.gov/pubmed/24722214
http://dx.doi.org/10.1371/journal.pone.0094507

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